scholarly journals P6439Therapeutic advantages of long-acting trimetazidine for the treatment of stable angina pectoris in routine clinical practice: findings from ODA trial

2018 ◽  
Vol 39 (suppl_1) ◽  
Author(s):  
M Glezer ◽  
V Vygodin ◽  
Keyword(s):  
Clinical Practice ◽  
Angina Pectoris ◽  
Stable Angina ◽  
Routine Clinical Practice ◽  
Stable Angina Pectoris ◽  
Long Acting

scholarly journals Nicorandil and Long-acting Nitrates: Vasodilator Therapies for the Management of Chronic Stable Angina Pectoris

2018 ◽  
Vol 13 (1) ◽  
pp. 23 ◽  
Author(s):  
Jason M Tarkin ◽  
Juan Carlos Kaski ◽  
◽  
◽  
Keyword(s):  
Angina Pectoris ◽  
Stable Angina ◽  
Chronic Stable Angina ◽  
Systemic Blood Pressure ◽  
Signalling Pathways ◽  
Stable Angina Pectoris ◽  
Systemic Blood ◽  
Long Acting ◽  
Chronic Use ◽  
Modest Reduction

Nicorandil and long-acting nitrates are vasodilatory drugs used commonly in the management of chronic stable angina pectoris. Both nicorandil and long-acting nitrates exert anti-angina properties via activation of nitric oxide (NO) signalling pathways, triggering vascular smooth muscle cell relaxation. Nicorandil has additional actions as an arterial K+ATP channel agonist, resulting in more “balanced” arterial and venous vasodilatation than nitrates. Ultimately, these drugs prevent angina symptoms through reductions in preload and diastolic wall tension and, to a lesser extent, epicardial coronary artery dilatation and lowering of systemic blood pressure. While there is some evidence to suggest a modest reduction in cardiovascular events among patients with stable angina treated with nicorandil compared to placebo, this prognostic benefit has yet to be proven conclusively. In contrast, there is emerging evidence to suggest that chronic use of long-acting nitrates might cause endothelial dysfunction and increased cardiovascular risk in some patients.

Short and long-acting oral nitrates for stable angina pectoris

1994 ◽  
Vol 8 (4) ◽  
pp. 611-623 ◽  
Author(s):  
Udho Thadani ◽  
Raymond J. Lipicky
Keyword(s):  
Angina Pectoris ◽  
Stable Angina ◽  
Stable Angina Pectoris ◽  
Long Acting

Chronic total coronary occlusions in patients with stable angina pectoris: impact on therapy and outcome in present day clinical practice

2009 ◽  
Vol 98 (7) ◽  
pp. 435-441 ◽  
Author(s):  
Gerald S. Werner ◽  
Anselm K. Gitt ◽  
Uwe Zeymer ◽  
Claus Juenger ◽  
Frank Towae ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Angina Pectoris ◽  
Stable Angina ◽  
Stable Angina Pectoris ◽  
Total Coronary Occlusions

Comparison of Nadolol, A New Long-Acting Beta-Receptor Blocking Agent, and Placebo in the Treatment of Stable Angina Pectoris

CHEST Journal ◽  
1981 ◽  
Vol 80 (4) ◽  
pp. 425-430 ◽  
Author(s):  
William Shapiro ◽  
Janet Park ◽  
Robert DiBianco ◽  
Steven N. Singh ◽  
Richard J. Katz ◽  
...  
Keyword(s):  
Angina Pectoris ◽  
Stable Angina ◽  
Blocking Agent ◽  
Stable Angina Pectoris ◽  
Receptor Blocking ◽  
Beta Receptor ◽  
Long Acting

Ivabradine in combination with beta-blocker therapy for the treatment of stable angina pectoris in every day clinical practice

2010 ◽  
Vol 99 (10) ◽  
pp. 665-672 ◽  
Author(s):  
Ralf Koester ◽  
Jan Kaehler ◽  
Henning Ebelt ◽  
Gerold Soeffker ◽  
Karl Werdan ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Angina Pectoris ◽  
Beta Blocker ◽  
Stable Angina ◽  
Stable Angina Pectoris ◽  
Blocker Therapy ◽  
Beta Blocker Therapy
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