Antibodies. to Hepatitis B Core Antigen in Hepatitis B Surface Antigen-Positive and -Negative Chronic Hepatitis

1977 ◽  
Vol 135 (6) ◽  
pp. 1006-1009 ◽  
Author(s):  
M. A. Gerber ◽  
T. Zappi ◽  
S. J. Vernace ◽  
F. Paronetto
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Surface Antigen ◽  
Hepatitis B Surface Antigen ◽  
Core Antigen ◽  
Hepatitis B Core Antigen ◽  
Negative Chronic Hepatitis

Radioimmunoassay for hepatitis B core antigen.

1982 ◽  
Vol 28 (2) ◽  
pp. 351-353 ◽  
Author(s):  
E Sagnelli ◽  
C Pereira ◽  
G Triolo ◽  
S Vernace ◽  
F Paronetto
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Competitive Inhibition ◽  
Hepatitis B Surface Antigen ◽  
Core Antigen ◽  
Positive Chronic Hepatitis ◽  
Hepatitis B Core Antigen ◽  
Commercial Kits ◽  
Dane Particles ◽  
Negative Chronic Hepatitis

Abstract Serum hepatitis B core antigen (HBcAg) is an important marker of hepatitis B virus replication. We describe an easy, sensitive radioimmunoassay for determination of HBcAg in detergent-treated serum pellets containing Dane particles. Components of a commercial kits for anti-core determination are used, and HBcAG is measured by competitive inhibition of binding of 125I-labeled antibodies to HBcAg with HBcAg-coated beads. We assayed of HBcAG in the sera of 49 patients with hepatitis B surface antigen (HBsAg)-positive chronic hepatitis, 50 patients with HBsAg-negative chronic hepatitis, and 30 healthy volunteers. HBcAg was detected in 41% of patients with HBsAg-positive chronic hepatitis but not in patients with HBsAg-negative chronic hepatitis. Hepatitis Be antigen (an antigen closely associated with the core of Dane particles) determined in the same sera by radioimmunoassay, was not detected in 50% of HBcAg-positive sera.

Hepatitis B surface antigen: Relation to hepatitis B replication parameters in HBeAg-negative chronic hepatitis B

2011 ◽  
Vol 55 (1) ◽  
pp. 61-68 ◽  
Author(s):  
Emanuel K. Manesis ◽  
George V. Papatheodoridis ◽  
Dina G. Tiniakos ◽  
Emilia S. Hadziyannis ◽  
Olga P. Agelopoulou ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Surface Antigen ◽  
Hepatitis B Surface Antigen ◽  
Negative Chronic Hepatitis
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