scholarly journals Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genes

2009 ◽  
Vol 21 (8) ◽  
pp. 947-955 ◽  
Author(s):  
Z. Sabouri ◽  
I.-m. Okazaki ◽  
R. Shinkura ◽  
N. Begum ◽  
H. Nagaoka ◽  
...  
Keyword(s):  
Somatic Hypermutation ◽  
Class Switch Recombination ◽  
Immunoglobulin Genes ◽  
Class Switch

scholarly journals In vivo and in vitro studies of immunoglobulin gene somatic hypermutation

2001 ◽  
Vol 356 (1405) ◽  
pp. 21-28 ◽  
Author(s):  
Julian E. Sale ◽  
Mats Bemark ◽  
Gareth T. Williams ◽  
Christopher J. Jolly ◽  
Michael R. Ehrenstein ◽  
...  
Keyword(s):  
Somatic Hypermutation ◽  
Class Switch Recombination ◽  
Variable Region ◽  
Immunoglobulin Gene ◽  
Immunoglobulin Genes ◽  
Class Switch ◽  
Immunoglobulin Repertoire ◽  
Genetic Events

Following antigen encounter, two distinct processes modify immunoglobulin genes. The variable region is diversified by somatic hypermutation while the constant region may be changed by class–switch recombination. Although both genetic events can occur concurrently within germinal centre B cells, there are examples of each occurring independently of the other. Here we compare the contributions of class–switch recombination and somatic hypermutation to the diversification of the serum immunoglobulin repertoire and review evidence that suggests that, despite clear differences, the two processes may share some aspects of their mechanism in common.

The inactivation of the XP-C gene does not affect somatic hypermutation or class switch recombination of immunoglobulin genes

1997 ◽  
Vol 34 (7) ◽  
pp. 527-533 ◽  
Author(s):  
Hong Ming Shen ◽  
David L. Cheo ◽  
Errol Friedberg ◽  
Ursula Storb
Keyword(s):  
Somatic Hypermutation ◽  
Class Switch Recombination ◽  
Immunoglobulin Genes ◽  
Class Switch

scholarly journals Author's reply: Apex2 is required for efficient somatic hypermutation but not for class switch recombination of immunoglobulin genes

2010 ◽  
Vol 22 (3) ◽  
pp. 213-214
Author(s):  
Z. Sabouri ◽  
I.-m. Okazaki ◽  
R. Shinkura ◽  
N. Begum ◽  
H. Nagaoka ◽  
...  
Keyword(s):  
Somatic Hypermutation ◽  
Class Switch Recombination ◽  
Immunoglobulin Genes ◽  
Class Switch

scholarly journals Cutting Edge: The G-U Mismatch Glycosylase Methyl-CpG Binding Domain 4 Is Dispensable for Somatic Hypermutation and Class Switch Recombination

2003 ◽  
Vol 170 (4) ◽  
pp. 1620-1624 ◽  
Author(s):  
Philip D. Bardwell ◽  
Alberto Martin ◽  
Edmund Wong ◽  
Ziqiang Li ◽  
Winfried Edelmann ◽  
...  
Keyword(s):  
Somatic Hypermutation ◽  
Class Switch Recombination ◽  
Binding Domain ◽  
Cutting Edge ◽  
Class Switch ◽  
Domain 4

The role of Apex2 in class-switch recombination of immunoglobulin genes

2010 ◽  
Vol 22 (3) ◽  
pp. 213-213 ◽  
Author(s):  
Jeroen E. J. Guikema ◽  
Janet Stavnezer ◽  
Carol E. Schrader
Keyword(s):  
Class Switch Recombination ◽  
Immunoglobulin Genes ◽  
Class Switch
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