Prevention and treatment of experimental influenza A virus infection in volunteers with a new antiviral ICI 130,685

1986 ◽  
Vol 18 (1) ◽  
pp. 119-129 ◽  
Author(s):  
W. Al-Nakib ◽  
P. G. Higgins ◽  
J. Willman ◽  
D. A. J. Tyrrell ◽  
D. L. Swallow ◽  
...  
Keyword(s):  
Virus Infection ◽  
Influenza A Virus ◽  
Influenza A ◽  
Prevention And Treatment ◽  
Influenza A Virus Infection ◽  
Experimental Influenza

scholarly journals Increased Interleukin-6 Levels in Nasal Lavage Samples following Experimental Influenza A Virus Infection

1998 ◽  
Vol 5 (5) ◽  
pp. 604-608 ◽  
Author(s):  
Deborah Gentile ◽  
William Doyle ◽  
Theresa Whiteside ◽  
Philip Fireman ◽  
Frederick G. Hayden ◽  
...  
Keyword(s):  
Virus Infection ◽  
Influenza A Virus ◽  
Interleukin 6 ◽  
Influenza A ◽  
Respiratory Infections ◽  
Nasal Lavage ◽  
Enzyme Linked Immunosorbent Assay ◽  
Influenza A Virus Infection ◽  
Systemic Symptoms ◽  
Experimental Influenza

ABSTRACT Interleukin-6 (IL-6) is a pleotropic cytokine implicated in the pathogenesis of local inflammation during viral upper respiratory infections. This study determined if experimental influenza A virus infection causes local IL-6 production. Seventeen healthy, adult subjects were intranasally inoculated, by course drops, with a safety-tested strain of influenza A/Kawasaki/86 (H1N1) virus. Nasal lavage samples were collected, symptoms were recorded, and expelled nasal secretions were weighed once before and then daily for 8 days after the virus inoculation. Lavage samples were submitted for virus culture and were examined for IL-6 and IL-4 by enzyme-linked immunosorbent assay. The IL-6, but not IL-4, levels were significantly increased in the nasal lavage samples of the 12 subjects who shed virus but not in those of the 5 subjects who did not shed virus. Moreover, the elevations in IL-6 levels were related temporally to the development of nasal symptoms and secretions but not to systemic symptoms. These results suggest a role for locally produced IL-6 in the pathogenesis and expressed symptomatology of influenza A virus infection.

Analysis of Different DNA Vaccines for Protection of Experimental Influenza A Virus Infection

2011 ◽  
Vol 24 (4) ◽  
pp. 321-330 ◽  
Author(s):  
Nadine Wiesener ◽  
Tatjana Schütze ◽  
Sara Lapp ◽  
Melissa Lehmann ◽  
Nadine Jarasch-Althof ◽  
...  
Keyword(s):  
Virus Infection ◽  
Influenza A Virus ◽  
Influenza A ◽  
Dna Vaccines ◽  
Influenza A Virus Infection ◽  
Experimental Influenza

scholarly journals Double-Blind Evaluation of Oral Ribavirin (Virazole) in Experimental Influenza A Virus Infection in Volunteers

1977 ◽  
Vol 12 (4) ◽  
pp. 498-502 ◽  
Author(s):  
C. R. Magnussen ◽  
R. G. Douglas ◽  
R. F. Betts ◽  
F. K. Roth ◽  
M. P. Meagher
Keyword(s):  
Virus Infection ◽  
Influenza A Virus ◽  
Influenza A ◽  
Double Blind ◽  
Influenza A Virus Infection ◽  
Experimental Influenza

scholarly journals Nasal Cytokine and Chemokine Responses in Experimental Influenza A Virus Infection: Results of a Placebo‐Controlled Trial of Intravenous Zanamivir Treatment

1999 ◽  
Vol 180 (3) ◽  
pp. 586-593 ◽  
Author(s):  
R. Scott Fritz ◽  
Frederick G. Hayden ◽  
David P. Calfee ◽  
Lindsey M. R. Cass ◽  
Amy W. Peng ◽  
...  
Keyword(s):  
Virus Infection ◽  
Influenza A Virus ◽  
Influenza A ◽  
Controlled Trial ◽  
Influenza A Virus Infection ◽  
Experimental Influenza

Abnormal middle ear pressures during experimental influenza A virus infection — role of Eustachian tube function

2000 ◽  
Vol 27 (4) ◽  
pp. 323-326 ◽  
Author(s):  
William J Doyle ◽  
James T Seroky ◽  
Betty L Angelini ◽  
Mehmet Gulhan ◽  
David P Skoner ◽  
...  
Keyword(s):  
Virus Infection ◽  
Influenza A Virus ◽  
Eustachian Tube ◽  
Middle Ear ◽  
Influenza A ◽  
Eustachian Tube Function ◽  
Tube Function ◽  
Influenza A Virus Infection ◽  
Experimental Influenza

Suppression of in vivo cell-mediated immunity during experimental influenza A virus infection of adults

1996 ◽  
Vol 38 (2) ◽  
pp. 143-153 ◽  
Author(s):  
David P. Skoner ◽  
Betty L. Angelini ◽  
Amy Jones ◽  
James Seroky ◽  
William J. Doyle ◽  
...  
Keyword(s):  
Virus Infection ◽  
Influenza A Virus ◽  
Influenza A ◽  
Cell Mediated Immunity ◽  
Influenza A Virus Infection ◽  
Experimental Influenza

scholarly journals Oral LY217896 for prevention of experimental influenza A virus infection and illness in humans.

1994 ◽  
Vol 38 (5) ◽  
pp. 1178-1181 ◽  
Author(s):  
F G Hayden ◽  
A R Tunkel ◽  
J J Treanor ◽  
R F Betts ◽  
S Allerheiligen ◽  
...  
Keyword(s):  
Virus Infection ◽  
Influenza A Virus ◽  
Influenza A ◽  
Influenza A Virus Infection ◽  
Experimental Influenza
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