scholarly journals Trends of antiretroviral drug resistance in treatment-naive patients with human immunodeficiency virus type 1 infection in Taiwan

2008 ◽  
Vol 61 (3) ◽  
pp. 689-693 ◽  
Author(s):  
S.-Y. Chang ◽  
M.-Y. Chen ◽  
C.-N. Lee ◽  
H.-Y. Sun ◽  
W. Ko ◽  
...  
2014 ◽  
Vol 30 (3) ◽  
pp. 294-298 ◽  
Author(s):  
Mukesh Kumar ◽  
Sourav Sen ◽  
Rakesh K. Gupta ◽  
Devidas Chaturbhuj ◽  
Srikanth P. Tripathy ◽  
...  

2009 ◽  
Vol 53 (9) ◽  
pp. 3611-3619 ◽  
Author(s):  
Michel L. Ntemgwa ◽  
Thomas d'Aquin Toni ◽  
Bluma G. Brenner ◽  
Ricardo J. Camacho ◽  
Mark A. Wainberg

Author(s):  
Siti Qamariyah Khairunisa ◽  
Ni Luh Ayu Megasari ◽  
Retno Pudji Rahayu ◽  
Adiana Mutamsari Witaningrum ◽  
Shuhei Ueda ◽  
...  

The presence of transmitted drug resist- ance (TDR) in human immunodeficiency virus type 1 (HIV-1) infected individuals naive to antiretroviral therapy, may affect the effectiveness of treatment. Jakarta, the capital city of Indonesia, recorded the high- est number of cumulative HIV infection cases in the country. This study aimed to identify on the appearance of TDR, as well as to identify HIV-1 subtypes circulating among treatment-naive individuals in Jakarta. Whole blood samples collected from 43 HIV-1 infected, treatment-naive individuals. Viral subtyping and drug resist- ance testing were performed on HIV-1 pol genes amplified using nested polymerase chain reaction. CRF01_AE was detected most frequently in Jakarta (73.08%). Drug resistance-related major mutation was not detected in protease fragments of pol gene, but two major mutations, K103N (6.67%) and Y181C (6.67%), were detected in reverse transcriptase fragments of pol gene. Our results suggest that TDR was emerged in Jakarta at a certain extent, thus further surveillance study to monitor the TDR prevalence and circulating HIV-1 subtypes in this region is considered to be necessary.


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