Laboratory Studies for the Evaluation of Systemic Lupus Erythematosus and Related Disorders

Lupus, Latin for “wolf,” is a term used to describe many dermatologic conditions, some of which are related to underlying systemic lupus erythematosus, while others are distinct disease processes. Cutaneous lupus erythematosus includes a wide array of visible skin manifestations and can progress to systemic lupus erythematosus in some cases. Cutaneous lupus can be subdivided into three main categories: acute cutaneous lupus erythematosus, subacute cutaneous lupus erythematosus, and chronic cutaneous lupus erythematosus. Physical exam, laboratory studies, and histopathology enable differentiation of cutaneous lupus subtypes. This differentiation is paramount as the subtype of cutaneous lupus informs upon treatment, disease monitoring, and prognostication. This review outlines the different cutaneous manifestations of lupus erythematosus and provides an update on both topical and systemic treatment options for these patients. Other conditions that utilize the term “lupus” but are not cutaneous lupus erythematosus are also discussed.

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A 4-year old presenting with fever and achiness

SAGE Open Medical Case Reports ◽

10.1177/2050313x211056416 ◽

2021 ◽

Vol 9 ◽

pp. 2050313X2110564

Author(s):

Caroline Plott ◽

Thomas Gracie ◽

Courtney Alvis ◽

Amanda Schlefman ◽

Robert Dudas

Keyword(s):

Systemic Lupus Erythematosus ◽

Lupus Erythematosus ◽

Correct Diagnosis ◽

Laboratory Studies ◽

Systemic Lupus ◽

Class V ◽

Pediatric Systemic Lupus Erythematosus ◽

System Disease ◽

Membranous Lupus Nephritis ◽

Onset Systemic Lupus Erythematosus

In children under the age of 5 who have abnormalities in history, physical examination, and laboratory studies indicating multi-system disease, uncovering the correct diagnosis is challenging. Here, we report the course of a 4-year-old girl who presented with a change in behavior, fever, arthralgia, arthritis, and hematuria following three recent hospitalizations for pneumonia and impetigo. Serologic findings were suggestive of a rheumatologic etiology and a renal biopsy was consistent with Membranous Lupus Nephritis Class V which helped secure the diagnosis of pediatric systemic lupus erythematosus. We review the clinical features and diagnostic criteria of early-onset systemic lupus erythematosus and discuss diagnostic considerations and prognosis.

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Laboratory Studies in Systemic Lupus Erythematosus

Archives of Dermatology ◽

10.1001/archderm.1956.01550040007002 ◽

1956 ◽

Vol 73 (4) ◽

pp. 313 ◽

Cited By ~ 4

Author(s):

STANLEY L. LEE

Keyword(s):

Systemic Lupus Erythematosus ◽

Lupus Erythematosus ◽

Laboratory Studies ◽

Systemic Lupus

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A clinical case of difficult diagnosis of systemic lupus erythematosus

Medical Science And Education Of Ural ◽

10.36361/1814-8999-2021-22-2-80-83 ◽

2021 ◽

Vol 22 (2) ◽

pp. 80-83

Author(s):

E. N. Ivanova ◽

◽

T. A. Mayorova ◽

S. S. Romanchenko ◽

T. V. Zuevskaya ◽

...

Keyword(s):

Systemic Lupus Erythematosus ◽

Differential Diagnosis ◽

Lupus Erythematosus ◽

Clinical Picture ◽

Clinical Case ◽

Intestinal Disease ◽

Extraintestinal Manifestations ◽

Laboratory Studies ◽

Systemic Lupus ◽

Difficult Diagnosis

The paper presents a clinical case of a patient diagnosed with systemic lupus erythematosus, which had a vague clinical picture and required a combined examination for differential diagnosis with intestinal disease (Crohn’s disease with extraintestinal manifestations). Data of instrumental, laboratory studies during hospitalization and data of pathoanatomic examination after death of the patient from the developed complications are presented.

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Organized Intraglomerular Deposits in NZB Mouse Disease

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100066772 ◽

1971 ◽

Vol 29 ◽

pp. 544-545

Author(s):

Francis R. Comerford ◽

Alan S. Cohen

Keyword(s):

Systemic Lupus Erythematosus ◽

Lupus Erythematosus ◽

Antinuclear Antibodies ◽

Human Systemic Lupus Erythematosus ◽

Systemic Lupus ◽

Glomerular Lesion ◽

Ultrastructural Studies ◽

Dense Deposits ◽

Experimental Nephritis ◽

Glomerular Lesions

Mice of the inbred NZB strain develop a spontaneous disease characterized by autoimmune hemolytic anemia, positive lupus erythematosus cell tests and antinuclear antibodies and nephritis. This disease is analogous to human systemic lupus erythematosus. In ultrastructural studies of the glomerular lesion in NZB mice, intraglomerular dense deposits in mesangial, subepithelial and subendothelial locations were described. In common with the findings in many examples of human and experimental nephritis, including many cases of human lupus nephritis, these deposits were amorphous or slightly granular in appearance with no definable substructure.We have recently observed structured deposits in the glomeruli of NZB mice. They were uncommon and were found in older animals with severe glomerular lesions by morphologic criteria. They were seen most commonly as extracellular elements in subendothelial and mesangial regions. The deposits ranged up to 3 microns in greatest dimension and were often adjacent to deposits of lipid-like round particles of 30 to 250 millimicrons in diameter and with amorphous dense deposits.

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