scholarly journals Structure and origin of a novel class of defective interfering particle of vesicular stomatitis virus

1984 ◽  
Vol 12 (6) ◽  
pp. 2775-2790 ◽  
Author(s):  
Stuart T. Nichol ◽  
Patrick J. O'Hara ◽  
John J. Holland ◽  
Jacques Perrault
Keyword(s):  
Vesicular Stomatitis Virus ◽  
Vesicular Stomatitis ◽  
Defective Interfering Particle

Comparison of vesicular stomatitis virus defective interfering particle synthesis in chick embryo and L cells

1976 ◽  
Vol 22 (10) ◽  
pp. 1458-1463 ◽  
Author(s):  
Kathleen N. Potter ◽  
Robert B. Stewart
Keyword(s):  
Chick Embryo ◽  
Vesicular Stomatitis Virus ◽  
Virus Replication ◽  
Infectious Virus ◽  
Particle Synthesis ◽  
Infectious Particle ◽  
L Cells ◽  
Vesicular Stomatitis ◽  
Defective Interfering Particle

A comparison of the ability of vesicular stomatitis virus (VSV) to generate and replicate defective interfering (DI) particles in primary chick embryo (CE) and mouse L cells was investigated as a means of analyzing host control over DI-particle synthesis and interfering capacity. Serial undiluted passage of VSV in CE and L cells indicate that VSV-DI particles are generated and (or) replicate with greater efficiency in CE than in L cells. When DI particles accumulate in L cells, they are able to interfere with infectious particle replication. The DI particles from CE cells interfered to the same extent with infectious particle replication in both CE and L cells. L cells, therefore, are not considered 'low-interference' hosts in which DI particles are produced and do not interfere with infectious virus replication, but rather hosts which restrict the production of DI particles.

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