P1277EFFECT OF HEMODIALYSIS ON PERIPAPILLARY CHOROIDAL THICKNESS AND OPTIC NERVE HEAD PARAMETERS MEASURED BY SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY
Abstract Background and Aims To investigate the effect of hemodialysis (HD) on peripapillary choroidal thickness (PCT) and optic nerve head (ONH) parameters by swept-source optical coherence (SS-OCT) and other ophthalmologic parameters in patients with end-stage kidney disease (ESKD). Method A prospective observational study was performed on 29 patients who underwent HD for ESKD. Detailed ophthalmologic examinations and SS-OCT were performed immediately before and after HD. The PCT were measured using the modification tool in the built-in OCT image viewer program. The ONH parameters including rim area (RA) and vertical cup-to-disc ratio (VCDR) were obtained using built-in software. Changes in PCT, and ONH parameters before and after HD were statistically analyzed. Results Average PCT significantly decreased from 127.3 ± 49.2 before HD to 117.1 ± 50.9 after HD (P<0.001). The RA increased and VCDR decreased significantly after HD (P=0.001 and P=0.027, respectively). Disc area did not show significant change after HD (P=0.648). Significant correlation was found between changes in PCT and changes in macular choroidal thickness (rho=0.547, P=0.002). Conclusion We observed significant decrease in PCT and significant changes in ONH parameters after HD. Our study suggest that HD can give influence on the ONH and its surrounding structure.