Macular and Peripapillary Choroidal Thickness Measured by Enhanced Depth Imaging Optical Coherence Tomography in Chinese Pregnant Women and Healthy No-Pregnant Women

Purpose: To evaluate macular, peripapillary choroidal thickness and retinal nerve fiber layer (RNFL) thickness in different trimesters and compare the measurements with those of healthy non-pregnant women. Methods: A prospective comparative study included 45 healthy pregnant women in first trimester, 90 women in second, 45 women in third trimesters and 45 healthy no-pregnant women as the control group. Macular choroidal thickness was measured at the subfoveal, 1mm temporal and 1mm nasal to the fovea using enhanced depth imaging optical coherence tomography (EDI-OCT). Peripapillary choroidal thickness and RNFL thickness parameters were automatically calculated by the Spectralis OCT. These parameters were analyzed among groups. Results: The subfoveal, temporal and nasal choroidal thickness were all significantly thicker in second trimesters, comparing with those parameters in first, third trimesters and the control group (all P<0.05). The peripapillary choroidal thickness was significantly increased at temporal, nasal, nasal inferior, temporal inferior and global positions during pregnancy among the 4 groups (all P<0.05). The RNFL thickness was also significantly increased in pregnant women at nasal superior and nasal inferior quadrants.Conclusions: Our results suggested that macular choroidal thickening appeared in second trimester. And peripapillary choroidal thickness and RNFL thickness also became thickening in pregnant women comparing with no-pregnant women as a whole.

P1277EFFECT OF HEMODIALYSIS ON PERIPAPILLARY CHOROIDAL THICKNESS AND OPTIC NERVE HEAD PARAMETERS MEASURED BY SWEPT-SOURCE OPTICAL COHERENCE TOMOGRAPHY

Background and Aims To investigate the effect of hemodialysis (HD) on peripapillary choroidal thickness (PCT) and optic nerve head (ONH) parameters by swept-source optical coherence (SS-OCT) and other ophthalmologic parameters in patients with end-stage kidney disease (ESKD). Method A prospective observational study was performed on 29 patients who underwent HD for ESKD. Detailed ophthalmologic examinations and SS-OCT were performed immediately before and after HD. The PCT were measured using the modification tool in the built-in OCT image viewer program. The ONH parameters including rim area (RA) and vertical cup-to-disc ratio (VCDR) were obtained using built-in software. Changes in PCT, and ONH parameters before and after HD were statistically analyzed. Results Average PCT significantly decreased from 127.3 ± 49.2 before HD to 117.1 ± 50.9 after HD (P&lt;0.001). The RA increased and VCDR decreased significantly after HD (P=0.001 and P=0.027, respectively). Disc area did not show significant change after HD (P=0.648). Significant correlation was found between changes in PCT and changes in macular choroidal thickness (rho=0.547, P=0.002). Conclusion We observed significant decrease in PCT and significant changes in ONH parameters after HD. Our study suggest that HD can give influence on the ONH and its surrounding structure.

Peripapillary choroidal thickness in eyes with high myopia

Objective To investigate characteristics of peripapillary choroidal thickness (PCT) in Chinese patients with myopia without myopic maculopathy. Methods We retrospectively assessed 95 Chinese patients (95 eyes) with myopia without myopic maculopathy, who had visited the myopia clinic of Shandong Provincial Qianfoshan Hospital. Thirteen patients were excluded; the remaining 82 patients were divided into Groups 1 (spherical equivalent [SE], −0.5 to −6.0 D; axial length, 24–26 mm; n = 26), 2 (SE, −6.0 to −10.0 D; axial length, 26 to 28 mm; n = 34), and 3 (SE, ≥−10.0 D; axial length, ≥28 mm; n = 22). Enhanced depth imaging optical coherence tomography was used to measure PCT in inferior, superior, nasal, and temporal quadrants. Continuous variables were compared using one-way analysis of variance. Associations of PCT with SE and axial length were analyzed by Pearson correlation. Results PCT decreased with increasing SE and axial length in all quadrants. For each group, PCT was thickest in the temporal quadrant and thinnest in the inferior quadrant. PCT significantly differed between Groups 1 and 3 in superior, nasal, and temporal quadrants. Conclusions PCT decreased with increasing SE and axial length. PCT was thickest in the temporal quadrant and thinnest in the inferior quadrant in Chinese patients with myopia.