scholarly journals The Protein Structure Initiative Structural Genomics Knowledgebase

2009 ◽  
Vol 23 (S1) ◽  
Author(s):  
Margaret Gabanyi ◽  
John Westbrook ◽  
Wendy Tao ◽  
Raship Shah ◽  
Andrei Kouranov ◽  
...  
Keyword(s):  
Protein Structure ◽  
Structural Genomics ◽  
Protein Structure Initiative

scholarly journals Protein Structure Initiative Material Repository: an open shared public resource of structural genomics plasmids for the biological community

2009 ◽  
Vol 38 (suppl_1) ◽  
pp. D743-D749 ◽  
Author(s):  
Catherine Y. Cormier ◽  
Stephanie E. Mohr ◽  
Dongmei Zuo ◽  
Yanhui Hu ◽  
Andreas Rolfs ◽  
...  
Keyword(s):  
Protein Structure ◽  
Structural Genomics ◽  
Protein Structure Initiative ◽  
Biological Community ◽  
Public Resource

scholarly journals The protein structure initiative structural genomics knowledgebase

2009 ◽  
Vol 37 (Database) ◽  
pp. D365-D368 ◽  
Author(s):  
H. M. Berman ◽  
J. D. Westbrook ◽  
M. J. Gabanyi ◽  
W. Tao ◽  
R. Shah ◽  
...  
Keyword(s):  
Protein Structure ◽  
Structural Genomics ◽  
Protein Structure Initiative

scholarly journals Trends in structural coverage of the protein universe and the impact of the Protein Structure Initiative

2014 ◽  
Vol 111 (10) ◽  
pp. 3733-3738 ◽  
Author(s):  
Kamil Khafizov ◽  
Carlos Madrid-Aliste ◽  
Steven C. Almo ◽  
Andras Fiser
Keyword(s):  
Protein Structure ◽  
Structural Genomics ◽  
Large Scale ◽  
Sequence Data ◽  
Taxonomic Composition ◽  
Protein Structure Initiative ◽  
Protein Sequence Data ◽  
Protein Universe ◽  
Structural Coverage ◽  
The Impact

The exponential growth of protein sequence data provides an ever-expanding body of unannotated and misannotated proteins. The National Institutes of Health-supported Protein Structure Initiative and related worldwide structural genomics efforts facilitate functional annotation of proteins through structural characterization. Recently there have been profound changes in the taxonomic composition of sequence databases, which are effectively redefining the scope and contribution of these large-scale structure-based efforts. The faster-growing bacterial genomic entries have overtaken the eukaryotic entries over the last 5 y, but also have become more redundant. Despite the enormous increase in the number of sequences, the overall structural coverage of proteins—including proteins for which reliable homology models can be generated—on the residue level has increased from 30% to 40% over the last 10 y. Structural genomics efforts contributed ∼50% of this new structural coverage, despite determining only ∼10% of all new structures. Based on current trends, it is expected that ∼55% structural coverage (the level required for significant functional insight) will be achieved within 15 y, whereas without structural genomics efforts, realizing this goal will take approximately twice as long.

scholarly journals Some Ill Considered Comments on the Protein Structure Initiative

Structure ◽  
2007 ◽  
Vol 15 (12) ◽  
pp. 1526-1527 ◽  
Author(s):  
Alex McPherson
Keyword(s):  
Protein Structure ◽  
Protein Structure Initiative

Protein Structure Initiative: getting into gear

2007 ◽  
Vol 14 (6) ◽  
pp. 459-460 ◽  
Author(s):  
Brian W Matthews
Keyword(s):  
Protein Structure ◽  
Protein Structure Initiative
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