scholarly journals The inhibition of phosphodiesterase 4 reduces skeletal muscle protein catabolism by suppressing autophagy/lysosomal and proteasomal pathways and atrophy‐specific gene transcription

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Eduardo Carvalho Lira ◽  
Lucas Tabajara Parreiras‐e‐Silva ◽  
Neusa Maria Zanon ◽  
Cláudio Miguel Costa Neto ◽  
Ísis Carmo Kettelhut ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Gene Transcription ◽  
Muscle Protein ◽  
Specific Gene ◽  
Protein Catabolism ◽  
Skeletal Muscle Protein ◽  
Phosphodiesterase 4

scholarly journals Growth Hormone and Insulin Reverse Net Whole Body and Skeletal Muscle Protein Catabolism in Cancer Patients

1992 ◽  
Vol 216 (3) ◽  
pp. 280-290 ◽  
Author(s):  
RONALD F. WOLF ◽  
DAVID B. PEARLSTONE ◽  
ELLIOT NEWMAN ◽  
MARTIN J. HESLIN ◽  
AMNON GONENNE ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Growth Hormone ◽  
Cancer Patients ◽  
Muscle Protein ◽  
Whole Body ◽  
Protein Catabolism ◽  
Skeletal Muscle Protein

Skeletal muscle degradation and nitrogen wasting in rats with chronic metabolic acidosis

1991 ◽  
Vol 80 (5) ◽  
pp. 457-462 ◽  
Author(s):  
Bryan Williams ◽  
Ellis Layward ◽  
John Walls
Keyword(s):  
Skeletal Muscle ◽  
Metabolic Acidosis ◽  
Time Course ◽  
Muscle Protein ◽  
Nitrogen Excretion ◽  
Protein Catabolism ◽  
Skeletal Muscle Protein ◽  
Body Protein ◽  
Chronic Metabolic Acidosis ◽  
Urea Production

1. Chronic metabolic acidosis is associated with impaired growth and negative nitrogen balance, suggesting that it promotes endogenous protein catabolism. 2. Skeletal muscle is the major repository of body protein and is a potential target for stimuli of protein catabolism. 3. This study in vivo examines the effects of chronic metabolic acidosis on the relationship between growth, nitrogen disposal and skeletal muscle catabolism in the rat. 4. Growth, nitrogen utilization and acquisition of body mass were significantly impaired in acidotic animals compared with pair-fed controls. 5. Total nitrogen excretion was significantly increased in acidotic rats despite decreased urea production. The time course of this response to acidosis was synchronous with that of accelerated protein catabolism in skeletal muscle. 6. It is proposed that metabolic acidosis impairs growth by stimulating skeletal muscle protein catabolism. It is suggested that this forms part of a co-ordinated multi-organ homoeostatic response to acidosis, skeletal muscle and down-regulated urea production supplying the nitrogen required for renal ammoniagenesis.

scholarly journals Skeletal muscle protein catabolism, protein anabolism, and myogenesis after various types of insults

2020 ◽  
Vol 54 (3) ◽  
pp. 139-142
Author(s):  
Yuko Ono ◽  
Masafumi Saito ◽  
Yoshihisa Fujinami ◽  
Shigeaki Inoue ◽  
Joji Kotani
Keyword(s):  
Skeletal Muscle ◽  
Muscle Protein ◽  
Protein Catabolism ◽  
Skeletal Muscle Protein

CYCLIC ADENOSINE MONOPHOSPHATE-PHOSPHODIESTERASE INHIBITORS REDUCE SKELETAL MUSCLE PROTEIN CATABOLISM IN SEPTIC RATS

Shock ◽  
2007 ◽  
Vol 27 (6) ◽  
pp. 687-694 ◽  
Author(s):  
Eduardo Carvalho Lira ◽  
Fl??via Aparecida Graca ◽  
Dawit Albieiro P. Goncalves ◽  
Neusa M. Zanon ◽  
Amanda Martins Baviera ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Protein ◽  
Phosphodiesterase Inhibitors ◽  
Cyclic Adenosine Monophosphate ◽  
Adenosine Monophosphate ◽  
Protein Catabolism ◽  
Skeletal Muscle Protein
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