Tracheal intubation without muscle relaxants: Probability and effect-site concentration of remifentanil for smooth intubation and provoking hypotension

2008 ◽  
Vol 25 (Sup 44) ◽  
pp. 148
Author(s):  
J. In ◽  
K. Kim ◽  
S. Lee ◽  
J. Yon ◽  
S. Chung
Keyword(s):  
Tracheal Intubation ◽  
Muscle Relaxants ◽  
Effect Site ◽  
Effect Site Concentration

Effect-site concentration of remifentanil for smooth tracheal intubation without muscle relaxants provokes hypotension under desflurane anesthesia

2008 ◽  
Vol 55 (1) ◽  
pp. 31 ◽  
Author(s):  
Junyong In ◽  
Hong-il Shin ◽  
Seung-hyun Chung ◽  
Kyoung-ok Kim ◽  
Jun Gwon Choi ◽  
...  
Keyword(s):  
Tracheal Intubation ◽  
Muscle Relaxants ◽  
Effect Site ◽  
Effect Site Concentration

Remifentanil Effect-site Concentration Blunting Cardiovascular Responses to Tracheal Intubation for Different Sex during Propofol Infusion

2007 ◽  
Vol 52 (5) ◽  
pp. 521 ◽  
Author(s):  
Hae Kwang Lee ◽  
Byung Hoon Yoo ◽  
Sang Seok Lee ◽  
Yun Hee Lim ◽  
Jun Heum Yon ◽  
...  
Keyword(s):  
Tracheal Intubation ◽  
Cardiovascular Responses ◽  
Effect Site ◽  
Effect Site Concentration

scholarly journals Changes of Hemodynamics and Bispectral Index by Tracheal Intubation according to Effect-site Concentration of Remifentanil during Propofol Anesthesia

2007 ◽  
Vol 53 (5) ◽  
pp. 565 ◽  
Author(s):  
Hong Sik Lee ◽  
Jang-Ho Song ◽  
Helen Ki Shinn ◽  
Jeong Uk Han ◽  
Jong-Kwon Jung ◽  
...  
Keyword(s):  
Tracheal Intubation ◽  
Bispectral Index ◽  
Effect Site ◽  
Effect Site Concentration

scholarly journals Effect-site concentration of remifentanil required to blunt haemodynamic responses during tracheal intubation: A randomized comparison between single- and double-lumen tubes

2017 ◽  
Vol 46 (1) ◽  
pp. 430-439
Author(s):  
Tae Kyong Kim ◽  
Deok Man Hong ◽  
Seo Hee Lee ◽  
Hyesun Paik ◽  
Se Hee Min ◽  
...  
Keyword(s):  
Tracheal Intubation ◽  
Lung Ventilation ◽  
Double Lumen Tube ◽  
One Lung Ventilation ◽  
Double Lumen ◽  
Lumen Tube ◽  
Effect Site ◽  
Target Controlled Infusion ◽  
Single Lumen ◽  
Effect Site Concentration

Objective To investigate the effect-site concentration of remifentanil required to blunt haemodynamic responses during tracheal intubation with a single-lumen tube (SLT) or a double-lumen tube (DLT). Methods Patients scheduled for thoracic surgery requiring one-lung ventilation were randomly allocated to either the SLT or DLT group. All patients received a target-controlled infusion of propofol and a predetermined concentration of remifentanil. Haemodynamic parameters during intubation were recorded. The effect-site concentration of remifentanil was determined using a delayed up-and-down sequential allocation method. Results A total of 92 patients were enrolled in the study. The effective effect-site concentrations of remifentanil required to blunt haemodynamic responses in 50% of patients (EC50) estimated by isotonic regression with bootstrapping was higher in the DLT than the SLT group (8.5 ng/ml [95% confidence interval (CI) 8.0–9.5 ng/ml] versus 6.5 ng/ml [95% CI 5.6–6.7 ng/ml], respectively). Similarly, the effective effect-site concentrations of remifentanil in 95% of patients in the DLT group was higher than the SLT group (9.9 ng/ml [95% CI 9.8–10.0 ng/ml] versus 7.0 ng/ml [95% CI 6.9–7.0 ng/ml], respectively). Conclusions This study demonstrated that a DLT requires a 30% higher EC50 of remifentanil than does an SLT to blunt haemodynamic responses during tracheal intubation when combined with a target-controlled infusion of propofol. Trial registration Clinicaltrials.gov identifier: NCT01542099.

Sign in / Sign up

Export Citation Format

Share Document