Limb ischemic preconditioning attenuates acute lung injury in haemorrhagic shock/resuscitation rats

We are describing a case of acute lung injury associated with uraemia and haemorrhagic shock. The treatment has consisted of the administration of repeated and equal doses of exogenous surfactant for 72 hours, starting within 48 hours from the beginning of the symptoms. A rapid improvement in the lung function has been detected, with consequent weaning from mechanical ventilation. The CT scan has confirmed the enhancement of atelectasis and hypoventilation. This case highlights the pivotal role of the administration of exogenous surfactant in selected cases of acute lung injury. If an anti-inflammatory effect is needed, we suppose that a repeated treatment with fractional dose is more effective.

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Remote Ischemic Preconditioning Protects against Post-Thoracotomy Acute Lung Injury: Chances and Challenges of Translation from Bench to Bedside

Journal of Anesthesia and Perioperative Medicine ◽

10.24015/japm.2015.0008 ◽

2015 ◽

Vol 2 (1) ◽

pp. 48-51

Author(s):

Fu-Shan Xue ◽

Rui-Ping Li ◽

Xin-Long Cui ◽

Gao-Pu Liu ◽

Chao Sun

Keyword(s):

Acute Lung Injury ◽

Lung Injury ◽

Ischemic Preconditioning ◽

Remote Ischemic Preconditioning

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Limb ischemic preconditioning mitigates lung injury induced by haemorrhagic shock/resuscitation in rats

Resuscitation ◽

10.1016/j.resuscitation.2011.02.010 ◽

2011 ◽

Vol 82 (6) ◽

pp. 760-766 ◽

Cited By ~ 18

Author(s):

Woan-Ching Jan ◽

Cay-Huyen Chen ◽

Pei-Shan Tsai ◽

Chun-Jen Huang

Keyword(s):

Lung Injury ◽

Ischemic Preconditioning ◽

Haemorrhagic Shock

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Remote ischemic preconditioning as prevention of transfusion-related acute lung injury

Medical Hypotheses ◽

10.1016/j.mehy.2014.05.016 ◽

2014 ◽

Vol 83 (3) ◽

pp. 273-275 ◽

Cited By ~ 2

Author(s):

Carlos R. Camara-Lemarroy

Keyword(s):

Acute Lung Injury ◽

Lung Injury ◽

Ischemic Preconditioning ◽

Remote Ischemic Preconditioning

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Remote ischemic preconditioning ameliorates indirect acute lung injury by modulating phosphorylation of IκBα in mice

Journal of International Medical Research ◽

10.1177/0300060518818300 ◽

2019 ◽

Vol 47 (2) ◽

pp. 936-950 ◽

Cited By ~ 3

Author(s):

Yun-Hee Kim ◽

Young-Sung Kim ◽

Byung-Hwa Kim ◽

Kuen-Su Lee ◽

Hyung-Sun Park ◽

...

Keyword(s):

Acute Lung Injury ◽

Lung Injury ◽

Ischemic Preconditioning ◽

Lavage Fluid ◽

Remote Ischemic Preconditioning ◽

Enzyme Linked Immunosorbent Assay ◽

Pulmonary Tissue ◽

Seriously Ill Patients ◽

The Right ◽

Seriously Ill

Objective Acute lung injury is responsible for mortality in seriously ill patients. Previous studies have shown that systemic inflammation is attenuated by remote ischemic preconditioning (RIPC) via reducing nuclear factor-kappa B (NF-κB). Therefore, we investigated whether lipopolysaccharide (LPS)-induced indirect acute lung injury (ALI) can be protected by RIPC. Methods RIPC was accomplished by 10 minutes of occlusion using a tourniquet on the right hind limb of mice, followed by 10 minutes of reperfusion. This process was repeated three times. Intraperitoneal LPS (20 mg/kg) was administered to induce indirect ALI. Inflammatory cytokines in bronchoalveolar lavage fluid were analyzed using an enzyme-linked immunosorbent assay. Pulmonary tissue was excised for histological examination, and for examining NF-κB activity and phosphorylation of inhibitor of κBα (IκBα). Results NF-κB activation and LPS-induced histopathological changes in the lungs were significantly alleviated in the RIPC group. RIPC reduced phosphorylation of IκBα in lung tissue of ALI mice. Conclusions RIPC attenuates endotoxin-induced indirect ALI. This attenuation might occur through modification of NF-κB mediation of cytokines by modulating phosphorylation of IκBα.

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