Hemodynamic Effects of a Selective Endothelin-A Receptor Antagonist in Deoxycorticosterone Acetate-Salt Hypertensive Rats

1998 ◽  
Vol 31 ◽  
pp. S262-S264 ◽  
Author(s):  
Ming Yu ◽  
Venkat Gopalakrishnan ◽  
J. Robert McNeill
Keyword(s):  
Receptor Antagonist ◽  
Hemodynamic Effects ◽  
Hypertensive Rats ◽  
Deoxycorticosterone Acetate ◽  
Acetate Salt ◽  
Endothelin A Receptor ◽  
Endothelin A

Acetylcholine-induced endothelium-derived contracting factor in hypoxic pulmonary hypertensive rats

1999 ◽  
Vol 86 (5) ◽  
pp. 1687-1695 ◽  
Author(s):  
Junko Maruyama ◽  
Ayumu Yokochi ◽  
Kazuo Maruyama ◽  
Shoichiro Nosaka
Keyword(s):  
Receptor Antagonist ◽  
Superoxide Anion ◽  
Pulmonary Arteries ◽  
Relaxation Response ◽  
Hypertensive Rats ◽  
Endothelin B Receptor ◽  
Endothelin A Receptor ◽  
Endothelin A ◽  
Endothelin B

We determined the role of an endothelium-derived contracting factor in the impaired relaxation response to ACh of conduit pulmonary arteries (PAs) isolated from rats with hypoxic pulmonary hypertension (PH). A PGH2/thromboxane A2(TxA2)-receptor antagonist (ONO-3708) partially restored the impairment of ACh-induced relaxation, whereas TxA2 synthase inhibitors (OKY-046 and CV-4151) did not affect the impaired relaxation in phenylephrine-precontracted hypertensive PAs. Endothelium-denuded hypertensive PA rings showed no difference in the response to ACh between preparations with and without ONO-3708. In both endothelium-denuded control and hypertensive PAs, exogenous PGH2 induced contractions, and the magnitude of the contractions was greater in the control than in hypoxic PH preparations. An endothelin A-receptor antagonist (BQ-485), an endothelin B-receptor antagonist (BQ-788), and a superoxide anion scavenger (superoxide dismutase) did not restore the impaired response to ACh in hypertensive PAs. These findings suggest that PGH2 produced from the conduit PAs of rats with chronic hypoxic PH may be the endothelium-derived contracting factor responsible for the impairment of ACh-mediated vasorelaxation.

The Selective Endothelin-A-Receptor Antagonist LU 135.252 Inhibits the Direct Arrhythmogenic Action of Endothelin-1

2000 ◽  
Vol 36 ◽  
pp. S314-S316 ◽  
Author(s):  
Béla Merkely ◽  
Tamás Szabó ◽  
László Gellér ◽  
Orsolya Kiss ◽  
Ferenc Horkay ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Endothelin 1 ◽  
Endothelin A Receptor ◽  
Endothelin A
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