Reduction of Progressive Burn Injury by Using a New Nonselective Endothelin-A and Endothelin-B Receptor Antagonist, TAK-044: An Experimental Study in Rats

1997 ◽  
Vol 99 (6) ◽  
pp. 1610-1619 ◽  
Author(s):  
Mehmet Nuri Battal ◽  
Yuiro Hata ◽  
Kazunori Matsuka ◽  
Osamu Ito ◽  
Hidenori Matsuda ◽  
...  
Keyword(s):  
Experimental Study ◽  
Receptor Antagonist ◽  
Burn Injury ◽  
Endothelin B Receptor ◽  
Endothelin A ◽  
Endothelin B

scholarly journals Endothelin-A Receptor Antagonist–Mediated Vasodilatation Is Attenuated by Inhibition of Nitric Oxide Synthesis and by Endothelin-B Receptor Blockade

Circulation ◽  
1998 ◽  
Vol 97 (8) ◽  
pp. 752-756 ◽  
Author(s):  
Marianne C. Verhaar ◽  
Fiona E. Strachan ◽  
David E. Newby ◽  
Nicholas L. Cruden ◽  
Hein A. Koomans ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Receptor Antagonist ◽  
Receptor Blockade ◽  
Nitric Oxide Synthesis ◽  
Endothelin B Receptor ◽  
Endothelin A Receptor ◽  
Endothelin A ◽  
Endothelin B

Acetylcholine-induced endothelium-derived contracting factor in hypoxic pulmonary hypertensive rats

1999 ◽  
Vol 86 (5) ◽  
pp. 1687-1695 ◽  
Author(s):  
Junko Maruyama ◽  
Ayumu Yokochi ◽  
Kazuo Maruyama ◽  
Shoichiro Nosaka
Keyword(s):  
Receptor Antagonist ◽  
Superoxide Anion ◽  
Pulmonary Arteries ◽  
Relaxation Response ◽  
Hypertensive Rats ◽  
Endothelin B Receptor ◽  
Endothelin A Receptor ◽  
Endothelin A ◽  
Endothelin B

We determined the role of an endothelium-derived contracting factor in the impaired relaxation response to ACh of conduit pulmonary arteries (PAs) isolated from rats with hypoxic pulmonary hypertension (PH). A PGH2/thromboxane A2(TxA2)-receptor antagonist (ONO-3708) partially restored the impairment of ACh-induced relaxation, whereas TxA2 synthase inhibitors (OKY-046 and CV-4151) did not affect the impaired relaxation in phenylephrine-precontracted hypertensive PAs. Endothelium-denuded hypertensive PA rings showed no difference in the response to ACh between preparations with and without ONO-3708. In both endothelium-denuded control and hypertensive PAs, exogenous PGH2 induced contractions, and the magnitude of the contractions was greater in the control than in hypoxic PH preparations. An endothelin A-receptor antagonist (BQ-485), an endothelin B-receptor antagonist (BQ-788), and a superoxide anion scavenger (superoxide dismutase) did not restore the impaired response to ACh in hypertensive PAs. These findings suggest that PGH2 produced from the conduit PAs of rats with chronic hypoxic PH may be the endothelium-derived contracting factor responsible for the impairment of ACh-mediated vasorelaxation.

Augmented Response of Endothelin-A and Endothelin-B Receptor Stimulation in Coronary Arteries of Hypertensive Hearts

1998 ◽  
Vol 31 ◽  
pp. S94-S98 ◽  
Author(s):  
Shigeyuki Miki ◽  
Kazuo Takeda ◽  
Masahiro Kiyama ◽  
Tsuguru Hatta ◽  
Satoshi Morimoto ◽  
...  
Keyword(s):  
Coronary Arteries ◽  
Receptor Stimulation ◽  
Endothelin B Receptor ◽  
Endothelin A ◽  
Endothelin B

Endothelin A but Not Endothelin B Receptor Blockade Reduces Capillary Permeability in Severe Experimental Pancreatitis

Pancreas ◽  
2002 ◽  
Vol 25 (2) ◽  
pp. e15-e20 ◽  
Author(s):  
Guido Eibl ◽  
Bence Forgacs ◽  
Hubert G. Hotz ◽  
Heinz J. Buhr ◽  
Thomas Foitzik
Keyword(s):  
Capillary Permeability ◽  
Experimental Pancreatitis ◽  
Receptor Blockade ◽  
Endothelin B Receptor ◽  
Endothelin A ◽  
Endothelin B
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