LIVER INJURY IN ISOLATED PERFUSED RAT LIVER PREPARATION EXPOSED TO CHLOROFORM

1962 ◽  
Vol 6 (2) ◽  
pp. 120???121
Author(s):  
R. W. BRAUER ◽  
G. F. LEONG ◽  
R. J. HOLLOWAY
Keyword(s):  
Liver Injury ◽  
Rat Liver ◽  
Isolated Perfused Rat Liver ◽  
Perfused Rat Liver ◽  
Liver Preparation

Liver injury in isolated perfused rat liver preparation exposed to chloroform

1961 ◽  
Vol 200 (6) ◽  
pp. 1348-1348 ◽  
Author(s):  
R. W. Brauer ◽  
G. F. Leong ◽  
R. J. Holloway
Keyword(s):  
Liver Injury ◽  
Rat Liver ◽  
Isolated Perfused Rat Liver ◽  
Perfused Rat Liver ◽  
Liver Preparation

Page 548: R. W. Brauer, G. F. Leong and R. J. Holloway, "Liver injury in isolated perfused rat liver preparation exposed to chloroform." Through an unfortunate oversight, throughout the text and figures, chloroform concentrations are referred to in terms of milligrams per liter instead of the correct unit of grams per liter. Thus, the chloroform levels employed and illustrated, for instance, in figure 2 should read 0.016 g/liter, etc.

Endogenous ET-1 contributes to liver injury induced by galactosamine and endotoxin in isolated perfused rat liver

1995 ◽  
Vol 268 (6) ◽  
pp. G997-G1003 ◽  
Author(s):  
T. Ohuchi ◽  
K. Tada ◽  
K. Akamatsu
Keyword(s):  
Liver Injury ◽  
Rat Liver ◽  
Early Event ◽  
Isolated Perfused Rat Liver ◽  
Perfused Rat Liver ◽  
Hepatic Microcirculation ◽  
Nonparenchymal Cells ◽  
Multiple Indicator Dilution ◽  
Microcirculatory Disturbances ◽  
Hepatocyte Damage

Injury to hepatocytes most likely occurs via disturbances in the microcirculation. The role of vasoconstriction due to the effect of endogenous endothelin-1 (ET-1) in the development of galactosamine (GalN)- and lipopolysaccharide (LPS)-induced liver injury was investigated. Using the multiple indicator dilution technique, we measured the volume of the hepatic sinusoids and the apparent Disse space as indicators of overall hepatic microcirculation. Serum purine nucleoside phosphorylase activity as a marker of damage to nonparenchymal cells increased and the volume of the sinusoids and the Disse space decreased prior to hepatocyte damage in rats treated intraperitoneally with GalN and LPS. Moreover, the amount of ET-1 release was elevated. When livers from untreated rats were perfused with ET-1 in a recirculating system, hepatocyte damage was observed similar to experiments with GalN and LPS. A monoclonal anti-endothelin antibody, AwETN40, diminished the extent of liver injury caused by GalN and LPS in isolated perfused rat liver. The present study suggests that vasoconstriction is an early event in GalN- and LPS-induced liver injury and that the development of hepatocyte damage is mediated via microcirculatory disturbances due to endogenous ET-1.

Role of neutrophils in ischemia/reperfusion liver injury. A study in the isolated perfused rat liver

1991 ◽  
Vol 13 ◽  
pp. S109
Author(s):  
O. Chazouillères ◽  
C. Legendre ◽  
M. Vaubourdolle ◽  
M.T. Bonnefis ◽  
C. Rey ◽  
...  
Keyword(s):  
Liver Injury ◽  
Rat Liver ◽  
Ischemia Reperfusion ◽  
Isolated Perfused Rat Liver ◽  
Perfused Rat Liver

The isolated perfused rat liver: Preparation and application

1987 ◽  
Vol 167 (1) ◽  
pp. 1-14 ◽  
Author(s):  
Allan W. Wolkoff ◽  
Kirsten L. Johansen ◽  
Tobias Goeser
Keyword(s):  
Rat Liver ◽  
Isolated Perfused Rat Liver ◽  
Perfused Rat Liver ◽  
Liver Preparation
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