EFFICACY AND SAFETY OF LONG-ACTING NIFEDIPINE (GITS) IN PATIENTS WITH DIABETES AND SYMPTOMATIC STABLE ANGINA PECTORIS: INSIGHTS FROM THE ACTION TRIAL: PP.17.118

2010 ◽  
Vol 28 ◽  
pp. e286
Author(s):  
HL Elliott ◽  
P Meredith
Keyword(s):  
Angina Pectoris ◽  
Stable Angina ◽  
Efficacy And Safety ◽  
Stable Angina Pectoris ◽  
Patients With Diabetes ◽  
Long Acting

scholarly journals Nicorandil and Long-acting Nitrates: Vasodilator Therapies for the Management of Chronic Stable Angina Pectoris

2018 ◽  
Vol 13 (1) ◽  
pp. 23 ◽  
Author(s):  
Jason M Tarkin ◽  
Juan Carlos Kaski ◽  
◽  
◽  
Keyword(s):  
Angina Pectoris ◽  
Stable Angina ◽  
Chronic Stable Angina ◽  
Systemic Blood Pressure ◽  
Signalling Pathways ◽  
Stable Angina Pectoris ◽  
Systemic Blood ◽  
Long Acting ◽  
Chronic Use ◽  
Modest Reduction

Nicorandil and long-acting nitrates are vasodilatory drugs used commonly in the management of chronic stable angina pectoris. Both nicorandil and long-acting nitrates exert anti-angina properties via activation of nitric oxide (NO) signalling pathways, triggering vascular smooth muscle cell relaxation. Nicorandil has additional actions as an arterial K+ATP channel agonist, resulting in more “balanced” arterial and venous vasodilatation than nitrates. Ultimately, these drugs prevent angina symptoms through reductions in preload and diastolic wall tension and, to a lesser extent, epicardial coronary artery dilatation and lowering of systemic blood pressure. While there is some evidence to suggest a modest reduction in cardiovascular events among patients with stable angina treated with nicorandil compared to placebo, this prognostic benefit has yet to be proven conclusively. In contrast, there is emerging evidence to suggest that chronic use of long-acting nitrates might cause endothelial dysfunction and increased cardiovascular risk in some patients.

Short and long-acting oral nitrates for stable angina pectoris

1994 ◽  
Vol 8 (4) ◽  
pp. 611-623 ◽  
Author(s):  
Udho Thadani ◽  
Raymond J. Lipicky
Keyword(s):  
Angina Pectoris ◽  
Stable Angina ◽  
Stable Angina Pectoris ◽  
Long Acting
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