Risk Stratification of Adult Patients Undergoing Orthotopic Liver Transplantation for Fulminant Hepatic Failure

2006 ◽  
Vol 81 (2) ◽  
pp. 195-201 ◽  
Author(s):  
Neal R. Barshes ◽  
Timothy C. Lee ◽  
Rajesh Balkrishnan ◽  
Saul J. Karpen ◽  
Beth A. Carter ◽  
...  
2016 ◽  
Vol 22 (4) ◽  
pp. 485-494 ◽  
Author(s):  
Joshua Weiner ◽  
Adam Griesemer ◽  
Eddie Island ◽  
Steven Lobritto ◽  
Mercedes Martinez ◽  
...  

Hepatology ◽  
1990 ◽  
Vol 11 (1) ◽  
pp. 59-64 ◽  
Author(s):  
Samuel A. Ockner ◽  
Elizabeth M. Brunt ◽  
Steven M. Cohn ◽  
Elaine S. Krul ◽  
Douglas W. Hanto ◽  
...  

2002 ◽  
Vol 25 (10) ◽  
pp. 929-934 ◽  
Author(s):  
L. Kramer ◽  
E. Bauer

Fulminant hepatic failure is a life-threatening clinical syndrome following severe hepatic injury leading to cerebral edema and brainstem herniation. Excessive mortality can be currently reduced only by timely orthotopic liver transplantation. Due to the shortage of donor organs, a considerable proportion of patients develop irreversible neurological damage, multiorgan failure or death while waiting for transplantation. Consequently, alternatives to orthotopic liver transplantation and methods of stabilizing patients on the waiting list including extracorporeal detoxification treatment are currently investigated. Recent advances in the pathophysiology of cerebral edema have challenged some of the traditional assumptions on which many blood detoxification systems are based. This article aims to integrate pathophysiology of hepatic encephalopathy and cerebral edema into a proposed future concept of liver support.


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