Use of Recombinant Human Bone Morphogenetic Protein-2 With Iliac Crest Bone Graft Instead of Iliac Crest Bone Graft Alone in Lumbar Spondylolysis

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Hao Meng ◽  
Yuan Gao ◽  
Guangmin Zhao ◽  
Tiansheng Sun ◽  
Fang Li
Keyword(s):  
Bone Graft ◽  
Bone Morphogenetic Protein ◽  
Iliac Crest ◽  
Human Bone ◽  
Bone Morphogenetic Protein 2 ◽  
Iliac Crest Bone Graft ◽  
Morphogenetic Protein ◽  
Lumbar Spondylolysis ◽  
Human Bone Morphogenetic Protein ◽  
Recombinant Human Bone

Effectiveness and Safety of Recombinant Human Bone Morphogenetic Protein-2 Versus Local Bone Graft in Primary Lumbar Interbody Fusions

Spine ◽  
2014 ◽  
Vol 39 (2) ◽  
pp. 164-171 ◽  
Author(s):  
Cameron Louis Adams ◽  
Kathryn Ogden ◽  
Iain Kilpatrick Robertson ◽  
Stephen Broadhurst ◽  
David Edis
Keyword(s):  
Bone Graft ◽  
Bone Morphogenetic Protein ◽  
Human Bone ◽  
Bone Morphogenetic Protein 2 ◽  
Local Bone ◽  
Morphogenetic Protein ◽  
Human Bone Morphogenetic Protein ◽  
Recombinant Human Bone

scholarly journals Lumbar interbody fusion after treatment with recombinant human bone morphogenetic protein–2 added to 70:30 poly(L-lactide-co-D,L-lactide) bioresorbable implants

2004 ◽  
Vol 16 (3) ◽  
pp. 1-4 ◽  
Author(s):  
Todd H. Lanman ◽  
Thomas J. Hopkins
Keyword(s):  
Bone Graft ◽  
Bone Morphogenetic Protein ◽  
Interbody Fusion ◽  
Human Bone ◽  
Bone Morphogenetic Protein 2 ◽  
Ct Scans ◽  
Lumbar Interbody Fusion ◽  
Morphogenetic Protein ◽  
Human Bone Morphogenetic Protein ◽  
Recombinant Human Bone

Object To evaluate the effectiveness of recombinant human bone morphogenetic protein–2 (rhBMP-2) combined with a bioresorbable implant, the authors conducted a prospective study of 43 patients with degenerative lumbar disc disease who underwent transforaminal lumbar interbody fusion. Methods The authors used Infuse bone graft, which consisted of rhBMP-2 applied to an absorbable collagen sponge and contained within a HYDROSORB Telamon bioresorbable implant to perform the fusion. Multilevel fusions were performed in 30% of the 43 patients, for a total of 57 levels. At 6 months postoperatively, x-ray films and computerized tomography (CT) scans demonstrated solid fusion in 98% of 41 patients. Improvement from the baseline Oswestry Disability Rating was demonstrated at 6 months postoperatively in 68% of the patients, based on the Oswestry Disability Questionnaire. At 12 months all 11 patients in whom CT scans were obtained showed complete bridging of bone; there were no device-related complications. Conclusions Results in this series provide evidence of the feasibility of using HYDROSORB Telamon biore-sorbable spacers in combination with Infuse bone graft for lumbar spine fusion.

scholarly journals Recombinant Human Bone Morphogenetic Protein-2 in Debridement and Impacted Bone Graft for the Treatment of Femoral Head Osteonecrosis

PLoS ONE ◽  
2014 ◽  
Vol 9 (6) ◽  
pp. e100424 ◽  
Author(s):  
Wei Sun ◽  
Zirong Li ◽  
Fuqiang Gao ◽  
Zhencai Shi ◽  
Qidong Zhang ◽  
...  
Keyword(s):  
Femoral Head ◽  
Bone Graft ◽  
Bone Morphogenetic Protein ◽  
Human Bone ◽  
Bone Morphogenetic Protein 2 ◽  
Femoral Head Osteonecrosis ◽  
Morphogenetic Protein ◽  
Human Bone Morphogenetic Protein ◽  
Recombinant Human Bone

scholarly journals Early findings in a pilot study of anterior cervical interbody fusion in which recombinant human bone morphogenetic protein–2 was used with poly(L-lactide-co-D,L-lactide) bioabsorbable implants

2004 ◽  
Vol 16 (3) ◽  
pp. 1-5 ◽  
Author(s):  
Todd H. Lanman ◽  
Thomas J. Hopkins
Keyword(s):  
Cervical Spine ◽  
Bone Graft ◽  
Bone Morphogenetic Protein ◽  
Spine Fusion ◽  
Human Bone ◽  
Bone Morphogenetic Protein 2 ◽  
Morphogenetic Protein ◽  
Human Bone Morphogenetic Protein ◽  
Cervical Spine Fusion ◽  
Recombinant Human Bone

Object The goal of this study was to assess the efficacy of bioabsorbable interbody spacers in cervical spine fusion. Methods The authors report on a prospective examination of 20 patients with degenerative cervical disc disease who underwent anterior cervical fusion at 28 total levels. The authors used Infuse bone graft (that is, recombinant human bone morphogenetic protein–2 applied to an absorbable collagen sponge and contained within a Cornerstone-HSR bioabsorbable spacer. Multiple-level fusions were performed in 30% of these patients. At 3 months postfusion, radiographs and computerized tomography scans demonstrated bridging bone in 100% of the patients. Improvement from baseline scores in physical functioning, mental health, and bodily pain was demonstrated at 3 months postoperatively according to results of the Short Form–36 Version 2 health survey. There were no device-related complications. Conclusions The results in this series indicate that the use of Cornerstone-HSR as a bioabsorbable interbody spacer in combination with Infuse bone graft may be an alternative treatment for cervical spine fusion.

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