Primary Cutaneous Alveolar Rhabdomyosarcoma in an Elderly Adult

The Human respiratory tract is colonized by a variety of microbes and the microbiota change as we age. In this perspective, literature support is presented for the hypothesis that the respiratory system microbiota could explain the differential age and sex breakdown amongst COVID-19 patients. The number of patients in the older and elderly adult group is higher than the other age groups. The perspective presents the possibility that certain genera of bacteria present in the respiratory system microbiota in children and young adults could be directly or through eliciting an immune response from the host, prevent full-fledged infection of SARS-CoV-2. The possibility also exists that the microbiota in older adults and the elderly population have bacteria that make it easier for the virus to cause infection. I call upon the scientific community to investigate the link between human microbiota and SARS-CoV-2 susceptibility to further understand the viral pathogenesis.

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PAX3/7-FOXO1 fusion-negative alveolar rhabdomyosarcoma in Schuurs-Hoeijmakers syndrome

Journal of Human Genetics ◽

10.1038/s10038-021-00965-3 ◽

2021 ◽

Author(s):

Teppei Ohkawa ◽

Akira Nishimura ◽

Kenjiro Kosaki ◽

Yuki Aoki-Nogami ◽

Daisuke Tomizawa ◽

...

Keyword(s):

Alveolar Rhabdomyosarcoma

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Pure alveolar rhabdomyosarcoma of the uterine corpus

Pathology International ◽

10.1111/j.1440-1827.2011.02672.x ◽

2011 ◽

Vol 61 (6) ◽

pp. 377-381 ◽

Cited By ~ 8

Author(s):

Masaharu Fukunaga

Keyword(s):

Alveolar Rhabdomyosarcoma ◽

Uterine Corpus

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AKT and PAX3-FKHR cooperation enforces myogenic differentiation blockade in alveolar rhabdomyosarcoma cell

Cell Cycle ◽

10.4161/cc.11.5.19346 ◽

2012 ◽

Vol 11 (5) ◽

pp. 895-908 ◽

Cited By ~ 19

Author(s):

Mathivanan Jothi ◽

Kochi Nishijo ◽

Charles Keller ◽

Asoke K. Mal

Keyword(s):

Myogenic Differentiation ◽

Alveolar Rhabdomyosarcoma ◽

Rhabdomyosarcoma Cell

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Caruncular Alveolar Rhabdomyosarcoma in a Woman Previously Treated for Breast Cancer

Archives of Ophthalmology ◽

10.1001/archophthalmol.2012.313 ◽

2012 ◽

Vol 130 (8) ◽

pp. 1087

Author(s):

Cory Ramstead ◽

Frank Buffam ◽

Valerie White

Keyword(s):

Breast Cancer ◽

Alveolar Rhabdomyosarcoma ◽

Previously Treated

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A Rare Case of Primary Anterior Mediastinal Yolk Sac Tumor in an Elderly Adult Male

Case Reports in Oncological Medicine ◽

10.1155/2016/8961486 ◽

2016 ◽

Vol 2016 ◽

pp. 1-4 ◽

Cited By ~ 2

Author(s):

Sammy G. Nakhla ◽

Srinath Sundararajan

Keyword(s):

Germ Cell ◽

Rare Case ◽

Germ Cell Tumors ◽

Anterior Mediastinum ◽

Yolk Sac ◽

Yolk Sac Tumor ◽

Elderly Adult ◽

Children And Young Adults ◽

Extragonadal Germ Cell Tumors ◽

Mediastinal Germ Cell Tumors

Mediastinal germ cell tumors are extragonadal germ cell tumors (EGGCTs) commonly seen in children and young adults. They are more common in men. Clinically they are classified as teratomas, seminomas, and nonseminomatous germ cell tumors. Primary mediastinal yolk sac neoplasm is an extremely rare tumor. We present here a very rare case of primary yolk sac tumor of the anterior mediastinum in a 73-year-old male. Mediastinal germ cell tumors have a worse prognosis than gonadal germ cell tumors. Chemotherapy followed by adjuvant surgery improves overall response in EGGCTs. However, comorbidities can render treatment with chemotherapy and surgery challenging in elderly patients.

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