Immune Processes and Pathogenic Fibrosis in Ocular Chronic Graft-Versus-Host Disease and Clinical Manifestations after Allogeneic Hematopoietic Stem Cell Transplantation

Cornea ◽  
2010 ◽  
Vol 29 ◽  
pp. S68-S77 ◽  
Author(s):  
Yoko Ogawa ◽  
Shigeto Shimmura ◽  
Murat Dogru ◽  
Kazuo Tsubota
Author(s):  
E. B. Machneva ◽  
V. Yu. Panarina ◽  
T. Z. Aliev ◽  
D. V. Shevtsov ◽  
A. M. Suleymanova ◽  
...  

Allogeneic hematopoietic stem cell transplantation (HSCT) is a potentially curative treatment for different spectrum of diseases. This type of treatment is constantly improving, but HSCT remains a risky procedure with various possible complications, the main is – chronic “graft versus host” disease (cGVHD). сGVHD is immune disregulation, and characterized by a variety of clinical manifestations that reflect the multiple underlying pathophysiology mechanisms. The study of cGVHD has now made great progress, but there’s still a lot of questions. General characteristics, risk-factors of development, clinical manifestations, pathogenesis of cGVHD will be discussed in this article. Clinical case presented in this article explains usage of basic and novel agents for cGVHD treatment, prevention criterions for treatment of cGVHD in children.


2016 ◽  
Vol 44 (10) ◽  
pp. 917-923 ◽  
Author(s):  
Jan-Moritz Doehn ◽  
Andreas Winkler ◽  
Zoya Kuzmina ◽  
Anastasiya Hladik ◽  
Hildegard Greinix ◽  
...  

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