Prohlatype: A Probabilistic Framework for HLA Typing
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AbstractHLA typing from sequencing data is considered as a classical probabilistic inference problem and Profile Hidden Markov Models (PHMM) are motivated for the likelihood calculation. Their generative property makes them a natural and highly discernible method; at the cost of considerable computation. We discuss ways to ameliorate this burden, and present an implementation https://github.com/hammerlab/prohlatype.
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2016 ◽
Vol 1864
(7)
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pp. 747-754
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2008 ◽
Vol 5
(2)
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pp. 151-169
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2016 ◽
Vol 41
(8)
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pp. 3267-3277
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2014 ◽
Vol 52
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pp. 51-59
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