Multiple inputs and multiple outputs (MIMO) relay cooperative transmission, as an efficient solution for high data rate and ubiquitous coverage, is a promising key technology for next generation wireless system. The performance of MIMO relay network is dependent on the signal processing approaches adopted by relay nodes. It is more complex when multiple users are active in MIMO relay network. Considering the minimum MSE problem, two sub-optimal algorithms are proposed based on the properties of relay filters. The simulation results the sub-optimal algorithms give similar results as optimal one.