In order to solve the problem of blind separation of signals from dynamic hybrid rotor systems, this paper proposed an improved adaptive inertial weight particle swarm optimization method based on genetic mechanism. The method takes the negative entropy of separated signal as the objective function and adaptively adjusts the inertia weight according to the difference of particle fitness, thus reducing the number of invalid iterations. At the same time, genetic hybridization mechanism was introduced to increase population diversity and facilitate the processing of dynamic mixed signals. The orthogonal matrix is expressed as a parameterized form, which can reduce the complexity of the algorithm. The simulation results showed that the performance of the proposed method is better than that of the traditional method for blind separation of dynamic hybrid analog mechanical signals. It can separate the actual dynamic rotor system signals and achieve the purpose of fault feature extraction.