Efficacy and safety of apremilast, an oral phosphodiesterase 4 inhibitor, in patients with moderate‐to‐severe plaque psoriasis over 52 weeks: a phase III, randomized controlled trial (ESTEEM 2)

British Journal of Dermatology ◽

10.1111/bjd.14164 ◽

2015 ◽

Vol 173 (6) ◽

pp. 1387-1399 ◽

Author(s):

C. Paul ◽

J. Cather ◽

M. Gooderham ◽

Y. Poulin ◽

U. Mrowietz ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Plaque Psoriasis ◽

Controlled Trial ◽

Phase Iii ◽

Efficacy And Safety ◽

Severe Plaque Psoriasis ◽

Phosphodiesterase 4 ◽

Randomized Controlled ◽

Phosphodiesterase 4 Inhibitor

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Faculty Opinions recommendation of Efficacy and safety of apremilast, an oral phosphodiesterase 4 inhibitor, in patients with moderate-to-severe plaque psoriasis over 52 weeks: a phase III, randomized controlled trial (ESTEEM 2).

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725781037.793521633 ◽

2016 ◽

Author(s):

Gil Yosipovitch ◽

Leigh Nattkemper

Keyword(s):

Randomized Controlled Trial ◽

Plaque Psoriasis ◽

Controlled Trial ◽

Phase Iii ◽

Efficacy And Safety ◽

Severe Plaque Psoriasis ◽

Phosphodiesterase 4 ◽

Randomized Controlled ◽

Phosphodiesterase 4 Inhibitor

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Apremilast, an oral phosphodiesterase 4 (PDE4) inhibitor, in patients with moderate to severe plaque psoriasis: Results of a phase III, randomized, controlled trial (Efficacy and Safety Trial Evaluating the Effects of Apremilast in Psoriasis [ESTEEM] 1)

Journal of the American Academy of Dermatology ◽

10.1016/j.jaad.2015.03.049 ◽

2015 ◽

Vol 73 (1) ◽

pp. 37-49 ◽

Author(s):

Kim Papp ◽

Kristian Reich ◽

Craig L. Leonardi ◽

Leon Kircik ◽

Sergio Chimenti ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Plaque Psoriasis ◽

Controlled Trial ◽

Phase Iii ◽

Pde4 Inhibitor ◽

Efficacy And Safety ◽

Severe Plaque Psoriasis ◽

Phosphodiesterase 4 ◽

Randomized Controlled

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FRI0447 Long-Term (156-Week) Efficacy and Safety Profile of Apremilast, An Oral Phosphodiesterase 4 Inhibitor, in Patients with Psoriatic Arthritis: Results from A Phase III, Randomized, Controlled Trial and Open-Label Extension (Palace 1)

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2016-eular.3256 ◽

2016 ◽

Vol 75 (Suppl 2) ◽

pp. 597.2-598

Author(s):

A. Kavanaugh ◽

D.D. Gladman ◽

J.J. Gomez-Reino ◽

S. Hall ◽

E. Lespessailles ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Controlled Trial ◽

Phase Iii ◽

Efficacy And Safety ◽

Phosphodiesterase 4 ◽

Randomized Controlled ◽

Open Label Extension ◽

Phosphodiesterase 4 Inhibitor

Download Full-text

217. Long-Term (104-Week) Efficacy and Safety Profile of Apremilast, an Oral Phosphodiesterase 4 Inhibitor, in Patients with Psoriatic Arthritis: Results from a Phase III, Randomized, Controlled Trial and Open-Label Extension (PALACE 1)

Rheumatology ◽

10.1093/rheumatology/kev089.104 ◽

2015 ◽

Keyword(s):

Randomized Controlled Trial ◽

Controlled Trial ◽

Phase Iii ◽

Efficacy And Safety ◽

Phosphodiesterase 4 ◽

Randomized Controlled ◽

Open Label Extension ◽

Phosphodiesterase 4 Inhibitor

Download Full-text

Two-year safety of apremilast, an oral phosphodiesterase 4 inhibitor, in patients with moderate to severe plaque psoriasis: Results from a phase 3, randomized, controlled trial (ESTEEM 1)

Journal of the American Academy of Dermatology ◽

10.1016/j.jaad.2015.02.1022 ◽

2015 ◽

Vol 72 (5) ◽

pp. AB256 ◽

Keyword(s):

Randomized Controlled Trial ◽

Plaque Psoriasis ◽

Controlled Trial ◽

Phase 3 ◽

Severe Plaque Psoriasis ◽

Phosphodiesterase 4 ◽

Randomized Controlled ◽

Phosphodiesterase 4 Inhibitor

Download Full-text

Apremilast, an oral phosphodiesterase 4 inhibitor, in the treatment of Japanese patients with moderate to severe plaque psoriasis: Efficacy, safety and tolerability results from a phase 2b randomized controlled trial

The Journal of Dermatology ◽

10.1111/1346-8138.13829 ◽

2017 ◽

Vol 44 (8) ◽

pp. 873-884 ◽

Author(s):

Mamitaro Ohtsuki ◽

Yukari Okubo ◽

Mayumi Komine ◽

Shinichi Imafuku ◽

Robert M. Day ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Plaque Psoriasis ◽

Controlled Trial ◽

Japanese Patients ◽

Severe Plaque Psoriasis ◽

Phosphodiesterase 4 ◽

Randomized Controlled ◽

Phosphodiesterase 4 Inhibitor

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Efficacy and safety of apremilast with or without topical or phototherapy: Subanalysis of the population with < PASI-75 in the ESTEEM 1 phase 3, randomized, controlled trial in patients with moderate to severe plaque psoriasis

Journal of the American Academy of Dermatology ◽

10.1016/j.jaad.2016.02.963 ◽

2016 ◽

Vol 74 (5) ◽

pp. AB246 ◽

Keyword(s):

Randomized Controlled Trial ◽

Plaque Psoriasis ◽

Controlled Trial ◽

Efficacy And Safety ◽

Phase 3 ◽

Severe Plaque Psoriasis ◽

Randomized Controlled

Download Full-text

Long-term safety and tolerability of apremilast, an oral phosphodiesterase 4 inhibitor, in patients with moderate to severe psoriasis: Results from a phase III, randomized, controlled trial (ESTEEM 1)

Journal of the American Academy of Dermatology ◽

10.1016/j.jaad.2014.01.722 ◽

2014 ◽

Vol 70 (5) ◽

pp. AB174 ◽

Keyword(s):

Randomized Controlled Trial ◽

Controlled Trial ◽

Severe Psoriasis ◽

Phase Iii ◽

Phosphodiesterase 4 ◽

Randomized Controlled ◽

Phosphodiesterase 4 Inhibitor

Download Full-text

Efficacy and safety results from a phase III, randomized controlled trial comparing the safety and efficacy of briakinumab with etanercept and placebo in patients with moderate to severe chronic plaque psoriasis

British Journal of Dermatology ◽

10.1111/j.1365-2133.2011.10419.x ◽

2011 ◽

Vol 165 (3) ◽

pp. 661-668 ◽

Author(s):

B.E. Strober ◽

J.J. Crowley ◽

P.S. Yamauchi ◽

M. Olds ◽

D.A. Williams

Keyword(s):

Randomized Controlled Trial ◽

Plaque Psoriasis ◽

Controlled Trial ◽

Phase Iii ◽

Efficacy And Safety ◽

Chronic Plaque Psoriasis ◽

Safety And Efficacy ◽

Randomized Controlled

Download Full-text

THU0416 Disease Activity and Safety During Long-Term (104-Week) Treatment with Apremilast, An Oral Phosphodiesterase 4 Inhibitor, in Patients with Psoriatic Arthritis: Results from a Phase III, Randomized, Controlled Trial and Open-Label Extension (Palace 3)

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2015-eular.2889 ◽

2015 ◽

Vol 74 (Suppl 2) ◽

pp. 348.2-349 ◽

Author(s):

C. Edwards ◽

F. Blanco ◽

J. Crowley ◽

C. Hu ◽

K. Shah ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Psoriatic Arthritis ◽

Controlled Trial ◽

Phase Iii ◽

Phosphodiesterase 4 ◽

Randomized Controlled ◽

Open Label Extension ◽

Phosphodiesterase 4 Inhibitor

Download Full-text