scholarly journals Characterisation of two tumour cell populations in the small cell variant of anaplastic lymphoma kinase‐positive anaplastic large cell lymphoma

Author(s):  
Kazuhiro Noguchi ◽  
Yasuhiro Ikawa ◽  
Mika Takenaka ◽  
Yuta Sakai ◽  
Toshihiro Fujiki ◽  
...  
2010 ◽  
Vol 134 (11) ◽  
pp. 1706-1710 ◽  
Author(s):  
Thomas A. Summers ◽  
Joel T. Moncur

Abstract Anaplastic large cell lymphomas constitute a heterogeneous group of hematopoietic neoplasms that are characterized by immunopositivity for CD30 and the presence, in varying degrees, of large, pleomorphic “hallmark” cells. Primary systemic anaplastic lymphoma kinase-positive anaplastic large cell lymphomas are a subset of this group. Numerous heterogeneous histomorphologic patterns have been described in anaplastic lymphoma kinase-positive anaplastic large cell lymphomas, and all patterns tend to have a better prognosis than that found in anaplastic lymphoma kinase-negative cases. We provide a short review of the small cell variant of anaplastic large cell lymphoma to facilitate the diagnosis of this difficult-to-recognize entity, which may be confused with reactive processes, commonly presents with disseminated disease, and pursues an aggressive clinical course.


2002 ◽  
Vol 25 (4) ◽  
pp. 271-274
Author(s):  
P. John Hunt ◽  
J. Nathan Hagstrom ◽  
Bradford J. Sherburne ◽  
Joseph A. DiGiuseppe ◽  
Richard W. Cartun

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