scholarly journals Ca2+-activated K+channel (KCa) stimulation improves relaxant capacity of PDE5 inhibitors in human penile arteries and recovers the reduced efficacy of PDE5 inhibition in diabetic erectile dysfunction

2013 ◽  
Vol 169 (2) ◽  
pp. 449-461 ◽  
Author(s):  
R González-Corrochano ◽  
JM La Fuente ◽  
P Cuevas ◽  
A Fernández ◽  
MX Chen ◽  
...  
Keyword(s):  
Erectile Dysfunction ◽  
K Channel ◽  
Pde5 Inhibitors ◽  
Pde5 Inhibition ◽  
Penile Arteries

L-cysteine/hydrogen sulfide pathway induces cGMP-dependent relaxation of corpus cavernosum and penile arteries from patients with erectile dysfunction and improves arterial vasodilation induced by PDE5 inhibition

2019 ◽  
Vol 863 ◽  
pp. 172675 ◽  
Author(s):  
José M. La Fuente ◽  
Argentina Fernández ◽  
Augusto J. Pepe-Cardoso ◽  
Juan I. Martínez-Salamanca ◽  
Nuno Louro ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Erectile Dysfunction ◽  
Corpus Cavernosum ◽  
Pde5 Inhibition ◽  
Penile Arteries

An update on new oral PDE5 inhibitors for the treatment of erectile dysfunction

2010 ◽  
Vol 7 (11) ◽  
pp. 603-609 ◽  
Author(s):  
Victor Palit ◽  
Ian Eardley
Keyword(s):  
Erectile Dysfunction ◽  
Pde5 Inhibitors

Substituted Pyrazolopyridopyridazines as Orally Bioavailable Potent and Selective PDE5 Inhibitors:  Potential Agents for Treatment of Erectile Dysfunction

2003 ◽  
Vol 46 (4) ◽  
pp. 457-460 ◽  
Author(s):  
Guixue Yu ◽  
Helen Mason ◽  
Ximao Wu ◽  
Jian Wang ◽  
Saeho Chong ◽  
...  
Keyword(s):  
Erectile Dysfunction ◽  
Pde5 Inhibitors ◽  
Orally Bioavailable

Quinolines as extremely potent and selective PDE5 inhibitors as potential agents for treatment of erectile dysfunction

2004 ◽  
Vol 14 (6) ◽  
pp. 1577-1580 ◽  
Author(s):  
Yingzhi Bi ◽  
Patrick Stoy ◽  
Leonard Adam ◽  
Bin He ◽  
John Krupinski ◽  
...  
Keyword(s):  
Erectile Dysfunction ◽  
Pde5 Inhibitors

PDE5 Inhibitors for the Treatment of Erectile Dysfunction in Patients with Hypertension

2014 ◽  
pp. 185-193
Author(s):  
Peter Kokkinos ◽  
Apostolos Tsimploulis ◽  
Charles Faselis
Keyword(s):  
Erectile Dysfunction ◽  
Pde5 Inhibitors

scholarly journals Efficacy and safety of PDE5 inhibitors in the treatment of diabetes mellitus erectile dysfunction

Medicine ◽  
2018 ◽  
Vol 97 (40) ◽  
pp. e12559 ◽  
Author(s):  
Xiao Li ◽  
Qi Zhao ◽  
Jingshang Wang ◽  
Jisheng Wang ◽  
Hengheng Dai ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Erectile Dysfunction ◽  
Efficacy And Safety ◽  
Pde5 Inhibitors ◽  
Treatment Of Diabetes

scholarly journals Audiometry Results and TEOAE and DPOAE Amplitudes in Men Taking a Phosphodiesterase Type 5 Inhibitor for Erectile Dysfunction

2017 ◽  
Vol 96 (7) ◽  
pp. E34-E39 ◽  
Author(s):  
Sertan Öntepeli ◽  
Nuray Bayar Muluk ◽  
Devrim Tuğlu ◽  
Timuçin Şipal
Keyword(s):  
Erectile Dysfunction ◽  
Otoacoustic Emissions ◽  
Pde5 Inhibitor ◽  
Post Treatment ◽  
Guanosine Monophosphate ◽  
Pde5 Inhibitors ◽  
Cochlear Blood Flow ◽  
Distortion Product ◽  
Phosphodiesterase Type 5 Inhibitor ◽  
Phosphodiesterase Type

We conducted a prospective study of transient evoked otoacoustic emissions (TEOAEs) and distortion-product otoacoustic emissions (DPOAEs) in men who were taking an oral phosphodiesterase type 5 (PDE5) inhibitor for erectile dysfunction. Our study group was made up of 30 men (60 ears), aged 34 to 60 years (mean: 50.9). They were randomly divided into three groups; 10 men were given sildenafil (Viagra) at 50 mg twice a week, 10 were given tadalafil (Cialis) at 20 mg twice a week, and 10 were given vardenafil (Levitra) at 20 mg twice a week. All patients took their drug for 3 weeks, for a total of 6 tablets for each patient. Audiometric tests and TEOAE and DPOAE measurements were performed before and after treatment. Post-treatment audiometry demonstrated improvement in hearing in all three groups. However, post-treatment TEOAE amplitudes and DPOAE amplitudes differed among the three groups; they were significantly higher in the sildenafil group at 1.0 kHz and the same in the tadalafil group; in the vardenafil group, the DPOAE amplitude was significantly lower at 3.0 kHz while there was no change in the TEOAE amplitude. We speculate that the possible mechanism for these findings is that PDE5 inhibitors block degradation of cyclic guanosine monophosphate (cGMP) and induce dilation of the cochlear microcirculation, resulting in an increase in cochlear blood flow. We also believe that the decrease in DPOAE amplitudes at 3.0 kHz seen in the vardenafil group may be related to an accumulation of nitric oxide/cGMP complex, which is toxic to the cochlea; however, since there was no change in TEOAE amplitude in the vardenafil group, this influence may be minimal. Further studies are needed to obtain a more comprehensive assessment of the effects of PDE5 inhibitors on hearing with the use of higher doses and longer durations of therapy.

scholarly journals Dr. Bang-Ping Jiann: PDE5 inhibitors in erectile dysfunction

2016 ◽  
Vol 5 (5) ◽  
pp. 806-807
Author(s):  
Lucine M. Gao
Keyword(s):  
Erectile Dysfunction ◽  
Pde5 Inhibitors

C32 The difference in treatment efficacy between long-acting and short-acting PDE5 inhibitors in patients with erectile dysfunction

2009 ◽  
Vol 8 (8) ◽  
pp. 668
Author(s):  
J. Bizjak ◽  
I. Bizjak ◽  
S. Hawlina ◽  
C. Oblak ◽  
K. Jagodič
Keyword(s):  
Erectile Dysfunction ◽  
Treatment Efficacy ◽  
Pde5 Inhibitors ◽  
Short Acting ◽  
The Difference ◽  
Long Acting
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