Drug rash with eosinophilia and systemic symptoms complicated by haemophagocytic lymphohistiocytosis: is screening required?

Author(s):  
K. Hussain ◽  
S. Zaheri ◽  
N. P. Patel
2003 ◽  
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Philippe Hovette
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RAOUDHA SLIM ◽  
MOHAMED DENGUEZLI ◽  
RAFIA NOUIRA ◽  
HOUSSEM HMOUDA ◽  
...  
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Cemil Tascioglu
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Vol 3 (3) ◽  
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Rannakoe J. Lehloenya ◽  
Sipho Dlamini ◽  
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Mzudumile R. Ngwanya ◽  
...  

Abstract Elimination of a rifamycin from the treatment regimen for tuberculosis negatively impacts outcomes. Cross-reactivity between the rifamycins after drug eruptions is unclear. We report 6 consecutive human immunodeficiency virus-infected patients with rifampicin-associated drug rash with eosinophilia and systemic symptoms (DRESS) syndrome confirmed on diagnostic rechallenge. The patients subsequently tolerated rifabutin. These data inform clinical management of tuberculosis-associated drug reactions.


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