Comment on caution against injudicious vaccine allergy skin test and adverse reactions after intradermal COVID ‐19 vaccine testing

Non-steroidal anti-inflammatory drugs are used daily by millions of patients worldwide for the management of various inflammatory diseases. Many well-documented adverse reactions are related to the use of these drugs. We report a fifty-four year-old woman with anaphylaxis after ingestion of ibuprofen liquid in a gelatin capsule. Eventually this was concluded to have resulted from hypersensitivity to the gelatin component of the capsule, which was likely IgE-mediated because of the positive skin test to gelatin. Gelatin allergy is only relevant for patients ingesting specific capsule formulation. The allergist/clinical immunologist must keep in mind the possibility of gelatin allergy.

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Caution against injudicious vaccine allergy skin tests: Adverse reactions after intradermal COVID‐19 vaccine testing

Contact Dermatitis ◽

10.1111/cod.13977 ◽

2021 ◽

Author(s):

Valerie Chiang ◽

Pearl P. T. Mong ◽

Edward K. K. Chan ◽

Elaine Y. L. Au ◽

Philip H. Li

Keyword(s):

Adverse Reactions ◽

Skin Tests ◽

Vaccine Testing

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Rate of Adverse Reactions to Penicillins and/or Cephalosporins are Low in Children with a Negative Penicillin Skin Test

Journal of Allergy and Clinical Immunology ◽

10.1016/j.jaci.2009.12.596 ◽

2010 ◽

Vol 125 (2) ◽

pp. AB152

Author(s):

S.J. Fox ◽

M.P. Park

Keyword(s):

Skin Test ◽

Adverse Reactions

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Sequential degranulation of eosinophils induced by antigen or autocoids in allergic humans

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100143390 ◽

1986 ◽

Vol 44 ◽

pp. 354-355

Author(s):

Kate W. Sjoerdsma ◽

W. James Metzger

Keyword(s):

Allergic Rhinitis ◽

Bronchoalveolar Lavage ◽

Allergic Asthma ◽

Skin Test ◽

Positive Skin Test ◽

Positive Skin ◽

Human Eosinophil ◽

Asthmatic Patients ◽

Allergic Asthmatic ◽

History Of

Eosinophils are important to the pathogenesis of allergic asthma, and are increased in bronchoalveolar lavage within four hours after bronchoprovocation of allergic asthmatic patients, and remain significantly increased up to 24 hours later. While the components of human eosinophil granules have been recently isolated and purified, the mechanisms of degranulation have yet to be elucidated.We obtained blood from two volunteers who had a history of allergic rhinitis and asthma and a positive skin test (5x5mm wheal) to Alternaria and Ragweed. Eosinophils were obtained using a modification of the method described by Roberts and Gallin.

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