Sequential degranulation of eosinophils induced by antigen or autocoids in allergic humans

1986 ◽  
Vol 44 ◽  
pp. 354-355
Author(s):  
Kate W. Sjoerdsma ◽  
W. James Metzger
Keyword(s):  
Allergic Rhinitis ◽  
Bronchoalveolar Lavage ◽  
Allergic Asthma ◽  
Skin Test ◽  
Positive Skin Test ◽  
Positive Skin ◽  
Human Eosinophil ◽  
Asthmatic Patients ◽  
Allergic Asthmatic ◽  
History Of

Eosinophils are important to the pathogenesis of allergic asthma, and are increased in bronchoalveolar lavage within four hours after bronchoprovocation of allergic asthmatic patients, and remain significantly increased up to 24 hours later. While the components of human eosinophil granules have been recently isolated and purified, the mechanisms of degranulation have yet to be elucidated.We obtained blood from two volunteers who had a history of allergic rhinitis and asthma and a positive skin test (5x5mm wheal) to Alternaria and Ragweed. Eosinophils were obtained using a modification of the method described by Roberts and Gallin.

Penicillin Hypersensitivity

1979 ◽  
Vol 1 (5) ◽  
pp. 132-158
Keyword(s):  
Skin Test ◽  
Multicenter Study ◽  
Positive Skin Test ◽  
Penicillin Allergy ◽  
Skin Tests ◽  
Penicillin G ◽  
Positive Skin ◽  
Positive History ◽  
History Of

A (massive) multicenter study of 3,000 patients has demonstrated that skin tests to penicillin G and penicilloyl-polylysine (PPL-now commercially available) predict and confirm penicillin allergy. Of patients with a history of penicillin reaction, 19% were positive to either, compared to 7% of controls. A history of anaphylaxis led to 46% positive. Of those with a history of urticaria 17% were positive, and those with maculopapular eruptions did not differ from controls (7% positive). Challenge with penicillin led to a reaction in 6% with a positive history (compared to 2% with a negative) and 67% with a combined positive history and positive skin test (to either).

scholarly journals Stress and anxiety effects on positive skin test responses in young adults with allergic rhinitis

2014 ◽  
Vol 113 (1) ◽  
pp. 13-18 ◽  
Author(s):  
Kathi L. Heffner ◽  
Janice K. Kiecolt-Glaser ◽  
Ronald Glaser ◽  
William B. Malarkey ◽  
Gailen D. Marshall
Keyword(s):  
Allergic Rhinitis ◽  
Young Adults ◽  
Skin Test ◽  
Positive Skin Test ◽  
Positive Skin

scholarly journals Comparison of Subject-Reported Allergy versus Skin Test Results in a Common Cold Trial

2003 ◽  
Vol 17 (3) ◽  
pp. 159-162
Author(s):  
Jason S. Krahnke ◽  
Deborah A. Gentile ◽  
Kelly M. Cordoro ◽  
Betty L. Angelini ◽  
Sheldon A. Cohen ◽  
...  
Keyword(s):  
Skin Test ◽  
Common Cold ◽  
Skin Testing ◽  
Positive Skin Test ◽  
Poor Correlation ◽  
Test Results ◽  
Positive Skin ◽  
Test Response ◽  
History Of ◽  
Allergy Skin Testing

Background Few studies have examined the relationship between subject-reported allergy and results of allergy skin testing in large unselected or unbiased cohorts. The objective of this study was to compare the results of self-reported allergy via verbal questioning with the results of allergy skin testing by the puncture method in 237 healthy adult subjects enrolled in a common cold study. Methods On enrollment, all subjects were verbally asked if they had a history of allergy and then underwent puncture skin testing to 19 relevant aeroallergens, as well as appropriate positive and negative controls. A skin test was considered positive if its wheal diameter was at least 3 mm larger than that obtained with the negative control. Results Forty-eight (20%) subjects reported a history of allergy and 124 (52%) subjects had at least one positive skin test response. A history of allergy was reported in 40 (32%) of the skin test-positive subjects and 8 (7%) of the skin test-negative subjects. At least one positive skin test response was found in 40 (83%) of those subjects reporting a history of allergy and 84 (44%) of those subjects denying a history of allergy. Conclusion These data indicate that there is a relatively poor correlation between self-reported history of allergy and skin test results in subjects enrolled in a common cold study. These results have implications in both clinical practice and research settings.

Stress and Anxiety Effects on Positive Skin Test Responses in Young Adults With Allergic Rhinitis

PEDIATRICS ◽  
2015 ◽  
Vol 136 (Supplement) ◽  
pp. S253-S254
Author(s):  
G. T. Padron ◽  
V. Hernandez-Trujillo
Keyword(s):  
Allergic Rhinitis ◽  
Young Adults ◽  
Skin Test ◽  
Positive Skin Test ◽  
Positive Skin

High Rate of Negative Results of Tuberculin and QuantiFERON Tests Among Individuals With a History of Positive Skin Test Results

2006 ◽  
Vol 27 (5) ◽  
pp. 436-441 ◽  
Author(s):  
Lloyd N. Friedman ◽  
Esther R. Nash ◽  
June Bryant ◽  
Susan Henry ◽  
Julia Shi ◽  
...  
Keyword(s):  
Skin Test ◽  
Significant Proportion ◽  
High Rate ◽  
Negative Group ◽  
Tuberculosis Screening ◽  
Positive Skin ◽  
Screening Programs ◽  
History Of ◽  
Positive Results

Objectives.To evaluate individuals at high risk for tuberculosis exposure who had a history of a positive tuberculin skin test (TST) result in order to determine the prevalence of unsuspected negative TST results. To confirm these findings with the QuantiFERON-TB test (QFT), an in vitro whole-blood assay that measures tuberculin-induced secretion of interferon-γ.Methods.This survey was conducted from November 2001 through December 2003 at 3 sites where TST screening is regularly done. Detailed histories and reviews of medical records were performed. TSTs were placed and read by 2 experienced healthcare workers, and blood was drawn for QFT. Any subject with a negative result of an initial TST during the study (induration diameter, <10 mm) underwent a second TST and a second QFT. The TST-negative group comprised individuals for whom both TSTs had an induration diameter of <10 mm. The confirmed-negative group comprised individuals for whom both TSTs yielded no detectable induration and results of both QFTs were negative.Results.A total of 67 immunocompetent subjects with positive results of a previous TST were enrolled in the study. Of 56 subjects who completed the TST protocol, 25 (44.6%; 95% confidence interval [CI], 31.6%-57.6%) were TST negative (P<.001). Of 31 subjects who completed the TST protocol and the QFT protocol, 8 (25.8%; 95% CI, 10.4%-41.2%) were confirmed negative (P<.005).Conclusions.A significant proportion of subjects with positive results of a previous TST were TST negative in this study, and a subset of these were confirmed negative. These individuals' TST status may have reverted or may never have been positive. It will be important in future studies to determine whether such individuals lack immunity to tuberculosis and whether they should be considered for reentry into tuberculosis screening programs.

Peanut allergy: Children who lose the positive skin test response

2001 ◽  
Vol 107 (3) ◽  
pp. 558-559 ◽  
Author(s):  
Barry Zimmerman ◽  
Bruce Urch
Keyword(s):  
Skin Test ◽  
Peanut Allergy ◽  
Positive Skin Test ◽  
Positive Skin ◽  
Test Response

scholarly journals Persistence of positive skin test 25 years after a penicillin-induced anaphylaxis

2015 ◽  
Vol 8 ◽  
pp. A87 ◽  
Author(s):  
Ana Carolina D'onofrio-Silva ◽  
Eduardo Longen ◽  
Marcelo Vivolo Aun ◽  
Marisa Rosimeire Ribeiro ◽  
Laila Sabino Garro ◽  
...  
Keyword(s):  
Skin Test ◽  
Positive Skin Test ◽  
Positive Skin

Successful Desensitization to Cetuximab in a Patient With a Positive Skin Test to Cetuximab and Specific IgE to Alpha-gal

2016 ◽  
Vol 26 (2) ◽  
pp. 132-134 ◽  
Author(s):  
JM García-Menaya ◽  
C Cordobés-Durán ◽  
J Gómez-Ulla ◽  
MA Zambonino ◽  
AC Mahecha ◽  
...  
Keyword(s):  
Skin Test ◽  
Specific Ige ◽  
Positive Skin Test ◽  
Positive Skin
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