Laparoscopic alternatives to fundoplication for gastroesophageal reflux: the role of magnetic augmentation and electrical stimulation of the lower esophageal sphincter

2015 ◽  
Vol 29 (8) ◽  
pp. 996-1001 ◽  
Author(s):  
L. Bonavina ◽  
S. Attwood
Keyword(s):  
Electrical Stimulation ◽  
Gastroesophageal Reflux ◽  
Lower Esophageal Sphincter ◽  
Esophageal Sphincter ◽  
Stimulation Of

scholarly journals Two-year results of intermittent electrical stimulation of the lower esophageal sphincter treatment of gastroesophageal reflux disease

Surgery ◽  
2015 ◽  
Vol 157 (3) ◽  
pp. 556-567 ◽  
Author(s):  
Leonardo Rodríguez ◽  
Patricia Rodriguez ◽  
Beatriz Gómez ◽  
Juan C. Ayala ◽  
Danny Oxenberg ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Lower Esophageal Sphincter ◽  
Reflux Disease ◽  
Esophageal Sphincter ◽  
Stimulation Of

Triggering of transient LES relaxations in ferrets: role of sympathetic pathways and effects of baclofen

2000 ◽  
Vol 279 (1) ◽  
pp. G157-G162 ◽  
Author(s):  
Esther Staunton ◽  
Scott D. Smid ◽  
John Dent ◽  
L. Ashley Blackshaw
Keyword(s):  
Gastroesophageal Reflux ◽  
Lower Esophageal Sphincter ◽  
Glucose Infusion ◽  
Gastric Distention ◽  
Low Level ◽  
Before And After ◽  
Esophageal Sphincter ◽  
Splanchnic Mechanoreceptors ◽  
High Level

Activation of gastric vagal mechanoreceptors by distention is thought to be the trigger for transient lower esophageal sphincter relaxations (TLESR), which lead to gastroesophageal reflux. The contribution of higher-threshold gastric splanchnic mechanoreceptors is uninvestigated. GABABreceptor agonists, including baclofen, potently reduce triggering of TLESR by low-level gastric distention. We aimed to determine first whether this effect of baclofen is maintained at high-level distention and second the role of splanchnic pathways in triggering TLESR. Micromanometric/pH studies in conscious ferrets showed that intragastric glucose infusion (25 ml) increased triggering of TLESR and reflux. Both were significantly reduced by baclofen (7 μmol/kg ip) ( P < 0.05). When 40 ml of air was added to the glucose infusion, more TLESR occurred than with glucose alone ( P < 0.01). These were also reduced by baclofen ( P < 0.001). TLESR after glucose/air infusion were assessed before and after splanchnectomy (2–4, 9–11, and 23–25 days), which revealed no change. Baclofen inhibits TLESR after both low- and high-level gastric distention. Splanchnic pathways do not contribute to increased triggering of TLESR by high-level gastric distention.

Long-term results of electrical stimulation of the lower esophageal sphincter for treatment of proximal GERD

2014 ◽  
Vol 28 (12) ◽  
pp. 3293-3301 ◽  
Author(s):  
Toshitaka Hoppo ◽  
Leonardo Rodríguez ◽  
Edy Soffer ◽  
Michael D. Crowell ◽  
Blair A. Jobe
Keyword(s):  
Electrical Stimulation ◽  
Lower Esophageal Sphincter ◽  
Long Term Results ◽  
Esophageal Sphincter ◽  
Stimulation Of

Mo1139 Modulation of Pulse Parameters for Electrical Stimulation of the Lower Esophageal Sphincter

2015 ◽  
Vol 148 (4) ◽  
pp. S-618
Author(s):  
Marc Cole ◽  
Takahide Kato ◽  
Stanley Yamashiro ◽  
Edy Soffer
Keyword(s):  
Electrical Stimulation ◽  
Lower Esophageal Sphincter ◽  
Pulse Parameters ◽  
Esophageal Sphincter ◽  
Stimulation Of
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