Cerebellar theta burst stimulation dissociates memory components in eyeblink classical conditioning

2014 ◽  
Vol 40 (9) ◽  
pp. 3363-3370 ◽  
Author(s):  
J. Monaco ◽  
C. Casellato ◽  
G. Koch ◽  
E. D'Angelo
Keyword(s):  
Classical Conditioning ◽  
Theta Burst Stimulation ◽  
Burst Stimulation ◽  
Theta Burst

scholarly journals Cerebellar Theta-Burst Stimulation Impairs Memory Consolidation in Eyeblink Classical Conditioning

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Jessica Monaco ◽  
Lorenzo Rocchi ◽  
Francesca Ginatempo ◽  
Egidio D'Angelo ◽  
John C. Rothwell
Keyword(s):  
Classical Conditioning ◽  
Cerebellar Nuclei ◽  
Cerebellar Hemisphere ◽  
Theta Burst Stimulation ◽  
Burst Stimulation ◽  
Deep Cerebellar Nuclei ◽  
Significant Impairment ◽  
Conditioned Responses ◽  
The Right ◽  
Theta Burst

Associative learning of sensorimotor contingences, as it occurs in eyeblink classical conditioning (EBCC), is known to involve the cerebellum, but its mechanism remains controversial. EBCC involves a sequence of learning processes which are thought to occur in the cerebellar cortex and deep cerebellar nuclei. Recently, the extinction phase of EBCC has been shown to be modulated after one week by cerebellar continuous theta-burst stimulation (cTBS). Here, we asked whether cerebellar cTBS could affect retention and reacquisition of conditioned responses (CRs) tested immediately after conditioning. We also investigated a possible lateralized cerebellar control of EBCC by applying cTBS on both the right and left cerebellar hemispheres. Both right and left cerebellar cTBSs induced a statistically significant impairment in retention and new acquisition of conditioned responses (CRs), the disruption effect being marginally more effective when the left cerebellar hemisphere was stimulated. These data support a model in which cTBS impairs retention and reacquisition of CR in the cerebellum, possibly by interfering with the transfer of memory to the deep cerebellar nuclei.

scholarly journals Cerebellar theta burst stimulation impairs eyeblink classical conditioning

2012 ◽  
Vol 590 (4) ◽  
pp. 887-897 ◽  
Author(s):  
Britt S. Hoffland ◽  
Matteo Bologna ◽  
Panagiotis Kassavetis ◽  
James T. H. Teo ◽  
John C. Rothwell ◽  
...  
Keyword(s):  
Classical Conditioning ◽  
Theta Burst Stimulation ◽  
Burst Stimulation ◽  
Theta Burst

Effects of combined inhibitory and excitatory theta-burst stimulation in healthy subjects

2009 ◽  
Vol 40 (01) ◽  
Author(s):  
AS Sarfeld ◽  
M Ameli ◽  
JT Teo ◽  
S Diekhoff ◽  
G Fink ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Theta Burst Stimulation ◽  
Burst Stimulation ◽  
Theta Burst

30 Hz Theta-burst Stimulation Over Primary Somatosensory Cortex Modulates Corticospinal Output to the Hand

2014 ◽  
Vol 7 (2) ◽  
pp. 269-274 ◽  
Author(s):  
Mark F. Jacobs ◽  
Philemon Tsang ◽  
Kevin G.H. Lee ◽  
Michael J. Asmussen ◽  
Christopher M. Zapallow ◽  
...  
Keyword(s):  
Somatosensory Cortex ◽  
Primary Somatosensory Cortex ◽  
Theta Burst Stimulation ◽  
Burst Stimulation ◽  
Theta Burst

Treatment of Auditory Hallucinations With Bilateral Theta Burst Stimulation: A Randomized Controlled Pilot Trial

2014 ◽  
Vol 7 (2) ◽  
pp. 340-341 ◽  
Author(s):  
Christian Plewnia ◽  
Bastian Zwissler ◽  
Barbara Wasserka ◽  
Andreas J. Fallgatter ◽  
Stefan Klingberg
Keyword(s):  
Pilot Trial ◽  
Auditory Hallucinations ◽  
Theta Burst Stimulation ◽  
Burst Stimulation ◽  
Randomized Controlled ◽  
Theta Burst

scholarly journals Therapeutic Use of Cerebellar Intermittent Theta Burst Stimulation (iTBS) in a Sardinian Family Affected by Spinocerebellar Ataxia 38 (SCA 38)

2021 ◽  
Author(s):  
Angela Sanna ◽  
Paolo Follesa ◽  
Paolo Tacconi ◽  
Mariangela Serra ◽  
Maria Giuseppina Pisu ◽  
...  
Keyword(s):  
Spinocerebellar Ataxia ◽  
Rating Scale ◽  
Clinical Symptoms ◽  
Therapeutic Use ◽  
Theta Burst Stimulation ◽  
Burst Stimulation ◽  
Motor Cortex Excitability ◽  
Before And After ◽  
Theta Burst ◽  
Serum Bdnf

AbstractSpinocerebellar ataxia 38 (SCA 38) is an autosomal dominant disorder caused by conventional mutations in the ELOVL5 gene which encodes an enzyme involved in the synthesis of very long fatty acids, with a specific expression in cerebellar Purkinje cells. Three Italian families carrying the mutation, one of which is of Sardinian descent, have been identified and characterized. One session of cerebellar intermittent theta burst stimulation (iTBS) was applied to 6 affected members of the Sardinian family to probe motor cortex excitability measured by motor-evoked potentials (MEPs). Afterwards, patients were exposed to ten sessions of cerebellar real and sham iTBS in a cross-over study and clinical symptoms were evaluated before and after treatment by Modified International Cooperative Ataxia Rating Scale (MICARS). Moreover, serum BDNF levels were evaluated before and after real and sham cerebellar iTBS and the role of BDNF Val66Met polymorphism in influencing iTBS effect was explored. Present data show that one session of cerebellar iTBS was able to increase MEPs in all tested patients, suggesting an enhancement of the cerebello-thalamo-cortical pathway in SCA 38. MICARS scores were reduced after ten sessions of real cerebellar iTBS showing an improvement in clinical symptoms. Finally, although serum BDNF levels were not affected by cerebellar iTBS when considering all samples, segregating for genotype a difference was found between Val66Val and Val66Met carriers. These preliminary data suggest a potential therapeutic use of cerebellar iTBS in improving motor symptoms of SCA38.

Sign in / Sign up

Export Citation Format

Share Document