Relationship between the neutrophil-to-lymphocyte ratio and silent cerebral small vessel disease in community-dwelling older adults. The Atahualpa Project

2017 ◽  
Vol 17 (12) ◽  
pp. 2637-2639 ◽  
Author(s):  
Aldo F. Costa ◽  
Mauricio Zambrano ◽  
Oscar H. Del Brutto
Keyword(s):  
Older Adults ◽  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
Community Dwelling ◽  
Neutrophil To Lymphocyte Ratio ◽  
Small Vessel ◽  
Lymphocyte Ratio ◽  
Vessel Disease ◽  
Atahualpa Project ◽  
Community Dwelling Older Adults

Cerebral small vessel disease in community-dwelling older adults living in remote rural settings

2020 ◽  
Vol 416 ◽  
pp. 117016 ◽  
Author(s):  
Oscar H. Del Brutto ◽  
Robertino M. Mera ◽  
Bettsy Y. Recalde ◽  
Victor J. Del Brutto
Keyword(s):  
Older Adults ◽  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
Community Dwelling ◽  
Small Vessel ◽  
Vessel Disease ◽  
Rural Settings ◽  
Community Dwelling Older Adults

scholarly journals Cognitive heterogeneity among community-dwelling older adults with cerebral small vessel disease

2019 ◽  
Vol 77 ◽  
pp. 183-193 ◽  
Author(s):  
Ayan K. Dey ◽  
Vessela Stamenova ◽  
Agnes Bacopulos ◽  
Nivethika Jeyakumar ◽  
Gary R. Turner ◽  
...  
Keyword(s):  
Older Adults ◽  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
Community Dwelling ◽  
Small Vessel ◽  
Vessel Disease ◽  
Cognitive Heterogeneity ◽  
Community Dwelling Older Adults

Cerebral small vessel disease score and atherosclerosis burden – A population study in community-dwelling older adults

2020 ◽  
Vol 194 ◽  
pp. 105795
Author(s):  
Oscar H. Del Brutto ◽  
Robertino M. Mera ◽  
Victor J. Del Brutto ◽  
John P. Hill ◽  
Andrew P. Torpey ◽  
...  
Keyword(s):  
Older Adults ◽  
Population Study ◽  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
Community Dwelling ◽  
Small Vessel ◽  
Disease Score ◽  
Vessel Disease ◽  
Community Dwelling Older Adults

scholarly journals 0805 Lack of Association Between Periodic Limb Movements of Sleep and Neuroimaging Signatures of Cerebral Small Vessel Disease in Stroke-Free Community-Dwelling Older Adults

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A306-A306
Author(s):  
K A Slota ◽  
P Castillo ◽  
R M Mera ◽  
V J Del Brutto ◽  
O H Del Brutto
Keyword(s):  
Older Adults ◽  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
Community Dwelling ◽  
Small Vessel ◽  
Periodic Limb Movements ◽  
Limb Movements ◽  
Vessel Disease ◽  
Independent Association ◽  
Community Dwelling Older Adults

Abstract Introduction Evidence of the relationship between periodic limb movements during sleep (PLMS) and cerebral small vessel disease (cSVD) is limited and inconsistent. Here, we aimed to assess the independent association between PLMS and the different neuroimaging signatures of cSVD. Methods Community dwelling adults aged ≥60 years enrolled in the Atahualpa Project undergoing PSG and MRI with time intervals ≤6 months were included. MRI readings focused on white matter hyperintensities (WMH) of presumed vascular origin, deep cerebral microbleeds (CMB), silent lacunar infarcts (LI), and >10 enlarged basal ganglia-perivascular spaces (BG-PVS). Data from single-night polysomnograms were interpreted according to recommendations of the American Academy of Sleep Medicine. Associations between the PLMS index and neuroimaging signatures of cSVD (as dependent variables) were assessed by means of logistic regression models, adjusted for relevant confounders. Results A total of 146 individuals (mean age: 71.4 ± 7.5 years; 64% women) were included. A PLMS index ≥15/hour were noted in 48 (33%) participants. Moderate-to-severe WMH were present in 33 individuals (23%), deep CMB in 9 (6%), silent LI in 16 (11%), and >10 BG-PVS in 44 (30%). In univariate analyses, silent LI (p=0.035) and the presence of >10 enlarged BG-PVS (p=0.034) were significantly higher among participants with a PLMS index ≥15/hour. However, fully-adjusted multivariate models showed no significant association between PLMS index ≥15/hour and any of the neuroimaging signatures of cSVD. Conclusion This study shows no independent association between the PLMS index and neuroimaging signatures of cSVD in stroke-free community-dwelling older adults. Support This study was supported by Universidad Espíritu Santo - Ecuador.

Dawson Fingers in Older Adults with Cerebral Small Vessel Disease: A Population Study

2020 ◽  
Vol 83 (4) ◽  
pp. 421-425
Author(s):  
Oscar H. Del Brutto ◽  
Robertino M. Mera ◽  
Aldo F. Costa ◽  
Patricia Silva ◽  
Victor J. Del Brutto
Keyword(s):  
Older Adults ◽  
White Matter ◽  
Small Vessel Disease ◽  
Brain Mri ◽  
Subcortical White Matter ◽  
Cerebral Small Vessel Disease ◽  
Community Dwelling ◽  
Small Vessel ◽  
Vessel Disease ◽  
Community Dwelling Older Adults

Dawson fingers are used to differentiate multiple sclerosis (MS) from other conditions that affect the subcortical white matter. However, there are no studies evaluating the presence of Dawson fingers in subjects with cerebral small vessel disease (cSVD). We aimed to assess prevalence and ­correlates of Dawson fingers in older adults with cSVD-related moderate-to-severe white matter hyperintensities (WMH). Community-dwelling older adults residing in rural Ecuador – identified by means of door-to-door surveys – underwent a brain MRI. Exams of individuals with cSVD-related moderate-to-severe WMH were reviewed with attention to the presence of Dawson fingers. Of 590 enrolled individuals, 172 (29%) had moderate-to-severe WMH. Of these, 18 (10.5%) had Dawson fingers. None had neurological manifestations suggestive of MS. Increasing age was independently associated with Dawson fingers (p = 0.017). Dawson fingers may be less specific for MS than previously thought. Concomitant damage of deep medullary veins may explain the presence of Dawson fingers in cSVD.

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