Extension of separation along the follicular epithelium and follicular basement membrane in pemphigus and bullous pemphigoid

2021 ◽  
Author(s):  
Rasha M. Genedy ◽  
Abdiwale Mohamed ◽  
Khaled El‐Mulla
Keyword(s):  
Basement Membrane ◽  
Bullous Pemphigoid ◽  
Follicular Epithelium

CHARACTERIZATION OF MONONUCLEAR CELLS AT THE BASEMENT MEMBRANE ZONE IN BULLOUS PEMPHIGOID

1992 ◽  
Vol 14 (1) ◽  
pp. 79
Author(s):  
Zillikens D. ◽  
Ambach A. ◽  
Klingert B. ◽  
Burg G.
Keyword(s):  
Basement Membrane ◽  
Bullous Pemphigoid ◽  
Mononuclear Cells ◽  
Basement Membrane Zone

A vesicular variant of bullous pemphigoid with autoantibodies against unidentified 205- and 150-kDa proteins at the basement membrane zone

1997 ◽  
Vol 137 (5) ◽  
pp. 768-773 ◽  
Author(s):  
S. SATOH ◽  
M. SEISHIMA ◽  
T. IZUMI ◽  
A. ITO ◽  
H. KAMIYA ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Bullous Pemphigoid ◽  
Basement Membrane Zone

BULLOUS PEMPHIGOID: INTERACTION OF INTERLEUKIN 5, ANTI-BASEMENT MEMBRANE ZONE ANTIBODIES AND EOSINOPHILS. A PRELIMINARY OBSERVATION

Cytokine ◽  
2001 ◽  
Vol 13 (1) ◽  
pp. 32-38 ◽  
Author(s):  
Leela Engineer ◽  
Kailash Bhol ◽  
Suman Kumari ◽  
A. Razzaque Ahmed
Keyword(s):  
Basement Membrane ◽  
Bullous Pemphigoid ◽  
Preliminary Observation ◽  
Basement Membrane Zone ◽  
Interleukin 5

Papules With Basement Membrane Zone Antibodies Preceding Bullous Pemphigoid

1982 ◽  
Vol 118 (11) ◽  
pp. 878
Author(s):  
Gérard Lorette
Keyword(s):  
Basement Membrane ◽  
Bullous Pemphigoid ◽  
Basement Membrane Zone

scholarly journals Laminin and Bullous Pemphigoid Antigen Are Distinct Basement Membrane Proteins Synthesized by Epidermal Cells

1982 ◽  
Vol 78 (6) ◽  
pp. 456-459 ◽  
Author(s):  
John R. Stanley ◽  
Pamela Hawley-Nelson ◽  
Mina Yaar ◽  
George R. Martin ◽  
Stephen I. Katz
Keyword(s):  
Membrane Proteins ◽  
Basement Membrane ◽  
Bullous Pemphigoid ◽  
Epidermal Cells ◽  
Bullous Pemphigoid Antigen ◽  
Basement Membrane Proteins

scholarly journals Gelatinase B–deficient Mice Are Resistant to Experimental Bullous Pemphigoid

1998 ◽  
Vol 188 (3) ◽  
pp. 475-482 ◽  
Author(s):  
Zhi Liu ◽  
J. Michael Shipley ◽  
Thiennu H. Vu ◽  
Xiaoye Zhou ◽  
Luis A. Diaz ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Bullous Pemphigoid ◽  
Neutrophil Infiltration ◽  
Basement Membrane Zone ◽  
Neutrophil Recruitment ◽  
Gelatinase B ◽  
Collagen Xvii ◽  
Blistering Disease ◽  
Novel Therapeutic Strategies ◽  
Deficient Mice

Bullous pemphigoid (BP) is an autoimmune subepidermal blistering disease characterized by deposition of autoantibodies at the basement membrane zone. In an experimental BP model in mice, the subepidermal blistering is mediated by antibodies directed against the hemidesmosomal protein BP180 (collagen XVII, BPAG2), and depends on complement activation and neutrophil infiltration. Gelatinase B is present in BP blister fluid and can cleave BP180. In this study we investigated the role of gelatinase B in the immunopathogenesis of experimental BP using mice containing targeted disruption of the gelatinase B (MMP-9, 92 kD gelatinase) gene. Gelatinase B–deficient mice were resistant to the blistering effect of intracutaneous anti-mBP180 antibodies, although these mice showed deposition of autoantibodies at the basement membrane zone and neutrophil recruitment to the skin comparable to that observed in the control mice. Interleukin 8 given intradermally concomitantly with pathogenic anti-mBP180 elicited a significant neutrophil recruitment into the skin in gelatinase B–deficient mice, but blistering did not occur. However, gelatinase B–deficient mice reconstituted with neutrophils from normal mice developed blistering in response to anti-mBP180 antibodies. These results implicate neutrophil-derived gelatinase B in the pathogenesis of experimental BP and might lead to novel therapeutic strategies for BP.

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