scholarly journals Amblyomma americanumtick saliva insulin-like growth factor binding protein-related protein 1 binds insulin but not insulin-like growth factors

2015 ◽  
Vol 24 (5) ◽  
pp. 539-550 ◽  
Author(s):  
Ž. M. Radulović ◽  
L. M. Porter ◽  
T. K. Kim ◽  
M. Bakshi ◽  
A. Mulenga
Keyword(s):  
Growth Factors ◽  
Growth Factor ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Related Protein ◽  
Factor Binding ◽  
Insulin Like Growth Factors

Influence of insulin-like growth factor-binding protein-2 on plasma clearance and transfer of insulin-like growth factors-I and -II from plasma into mammary-derived lymph and milk of goats

1996 ◽  
Vol 150 (1) ◽  
pp. 121-127 ◽  
Author(s):  
C G Prosser ◽  
J Schwander
Keyword(s):  
Growth Factors ◽  
Growth Factor ◽  
Plasma Clearance ◽  
Binding Protein ◽  
Plasma Concentrations ◽  
Insulin Like Growth Factor ◽  
Factor Binding ◽  
Lactating Goats ◽  
Igf I ◽  
Insulin Like Growth Factors

Abstract Plasma clearance of insulin-like growth factors-I and -II (IGF-I and -II) and insulin-like growth factor-binding protein-2 (IGFBP-2) from lactating goats (n=4) was determined following a single intravenous injection of the corresponding 125I-labelled human protein. Transfer of these proteins out of the vascular space was monitored by their subsequent appearance in mammary-derived lymph and milk. Clearance of 125I-IGFBP-2 from circulation was 0·37 ± 0·06 ml/min/kg, which is markedly greater than that of 125I-IGF-I or -II (0·11 ± and 0·12 ± 0·01 ml/min/kg respectively). This was also reflected in longer elimination half-lives for IGF-I (353 ± 6 min) and -II (254 ± 8 min) compared with IGFBP-2 (110 ± 9 min). Three hours after injection of the 125I-labelled protein, the plasma:lymph ratio of trichloroacetic acid-precipitable radioactivity was 1·54 ±0·04, 3·3 ±0·6 and 4·1 ±0·4 for IGFBP-2, IGF-I and -II respectively. The form of 125I-IGFBP-2 in lymph was not different from that of plasma. Elevation of plasma concentrations of IGFBP-2 by its intravenous infusion significantly decreased plasma half-life of both IGF-I and -II (251 ± 8 and 198 ±7 min respectively). Although the amount and rate of transfer of IGF into mammary-derived lymph was decreased slightly by IGFBP-2, concentrations eventually obtained were not different from control. However, secretion of IGFs into milk was significantly reduced by IGFBP-2, particularly in the case of IGF-I. These results are consistent with the ability of all three compounds to cross the vascular endothelium intact and of IGFBP-2 to decrease the uptake of IGF by mammary epithelium and subsequent secretion into milk. IGFBP-2 may well have acted to target plasma IGF towards non-mammary tissues, thus explaining the more rapid plasma clearance of IGFs in the presence of elevated IGFBP-2. Journal of Endocrinology (1996) 150, 121–127

scholarly journals Transferrin binds insulin-like growth factors and affects binding properties of insulin-like growth factor binding protein-3

FEBS Letters ◽  
2001 ◽  
Vol 509 (3) ◽  
pp. 395-398 ◽  
Author(s):  
Stephan Storch ◽  
Bernd Kübler ◽  
Stefan Höning ◽  
Michael Ackmann ◽  
Jürgen Zapf ◽  
...  
Keyword(s):  
Growth Factors ◽  
Growth Factor ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
Binding Properties ◽  
Factor Binding ◽  
Insulin Like Growth Factors

Nutrient Balance and Stage of Lactation Affect Responses of Insulin, Insulin-Like Growth Factors I and II, and Insulin-Like Growth Factor-Binding Protein 2 to Somatotropin Administration in Dairy Cows

1991 ◽  
Vol 121 (10) ◽  
pp. 1656-1664 ◽  
Author(s):  
John L. Vicini ◽  
Frances C. Buonomo ◽  
Jeffrey J. Veenhuizen ◽  
Margaret A. Miller ◽  
David R. Clemmons ◽  
...  
Keyword(s):  
Growth Factors ◽  
Growth Factor ◽  
Dairy Cows ◽  
Binding Protein ◽  
Nutrient Balance ◽  
Insulin Like Growth Factor ◽  
Factor Binding ◽  
Stage Of Lactation ◽  
Insulin Like Growth Factors

C-peptide, insulin-like growth factors I and II, and insulin-like growth factor binding protein-1 in umbilical cord serum: Correlations with birth weight

1993 ◽  
Vol 169 (1) ◽  
pp. 89-97 ◽  
Author(s):  
Johan Verhaeghe ◽  
Rita Van Bree ◽  
Erik Van Herck ◽  
Jozef Laureys ◽  
Roger Bouillon ◽  
...  
Keyword(s):  
Growth Factors ◽  
Birth Weight ◽  
Growth Factor ◽  
Umbilical Cord ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
C Peptide ◽  
Factor Binding ◽  
Cord Serum ◽  
Insulin Like Growth Factors

C-peptide, insulin-like growth factors I and II, and insulin-like growth factor binding protein-1 in cord serum of twins: Genetic versus environmental regulation

1996 ◽  
Vol 175 (5) ◽  
pp. 1180-1188 ◽  
Author(s):  
Johan Verhaeghe ◽  
Ruth Loos ◽  
Robert Vlietinck ◽  
Erik Van Herckb ◽  
Rita van Breea ◽  
...  
Keyword(s):  
Growth Factors ◽  
Growth Factor ◽  
Environmental Regulation ◽  
Binding Protein ◽  
Insulin Like Growth Factor ◽  
C Peptide ◽  
Factor Binding ◽  
Cord Serum ◽  
Insulin Like Growth Factors
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