Acute adrenal failure due to bilateral adrenal haemorrhage associated with lupus anticoagulant antibodies

2015 ◽  
Vol 45 (1) ◽  
pp. 119-120
Author(s):  
E. L. Potter ◽  
S. L. Barnes ◽  
S. D. Chunilal
Keyword(s):  
Lupus Anticoagulant ◽  
Adrenal Failure ◽  
Adrenal Haemorrhage ◽  
Acute Adrenal Failure

scholarly journals Acute adrenal failure as the heralding symptom of primary antiphospholipid syndrome: report of a case and review of the literature

2005 ◽  
Vol 153 (4) ◽  
pp. 507-514 ◽  
Author(s):  
Fabio Presotto ◽  
Francesca Fornasini ◽  
Corrado Betterle ◽  
Giovanni Federspil ◽  
Marco Rossato
Keyword(s):  
Abdominal Pain ◽  
Adrenal Insufficiency ◽  
Antiphospholipid Syndrome ◽  
Great Majority ◽  
Primary Antiphospholipid Syndrome ◽  
Adrenal Failure ◽  
Adrenal Haemorrhage ◽  
Morphological Findings ◽  
Acute Adrenal Insufficiency ◽  
Acute Adrenal Failure

Acute adrenal failure is a potentially fatal condition if overlooked. Occasionally, acute adrenal insufficiency may ensue from bilateral adrenal haemorrhage in patients with known antiphospholipid syndrome (APS). APS is characterized by recurrent arterial and venous thrombosis, pregnancy complications and detection of autoantibodies to phospholipids. This syndrome may be associated with non-organ specific diseases (e.g. connective tissue disorders) or with malignancies, but it may also appear in isolated form (primary APS). In a very few cases the heralding manifestation is given by adrenal failure. We report here a 63-year-old man presenting with acute adrenal insufficiency as the opening clinical manifestation of an APS. We also carried out a computer-aided search of the literature to identify all cases of primary adrenal failure as the first-recognized expression of a primary APS, a condition that not so infrequently may be tackled by endocrinologists. 20 patients fulfilled the inclusion criteria. The great majority of them were males (75%) with a mean age of 42 years. Abdominal pain was present in 14 patients, followed by fever (13 patients) and hypotension (12 patients). The main morphological findings by computed tomography or magnetic resonance were consistent with bilateral adrenal haemorrhage in 11 patients. Lupus anticoagulant was present in all of the 19 tested patients. Our observations emphasize the importance in the assessment of clotting times, and possibly of antiphospholipid antibodies, in all patients with diagnosis of rapidly progressive adrenal failure and concurrent abdominal pain.

scholarly journals Lupus anticoagulant hypoprothrombinemia syndrome associated with bilateral adrenal haemorrhage in a child: early diagnosis and intervention

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Atsushi Sakamoto ◽  
Masao Ogura ◽  
Atsushi Hattori ◽  
Kinji Tada ◽  
Reiko Horikawa ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Lupus Anticoagulant ◽  
Clinical Manifestations ◽  
Screening Tests ◽  
Adrenal Failure ◽  
Adrenal Haemorrhage ◽  
Systemic Lupus ◽  
Life Threatening

Abstract Background Lupus anticoagulant-hypoprothrombinemia syndrome (LAHPS) is characterized by bleeding and thrombosis in patients with autoimmune diseases or infections. Paediatric LAHPS exhibits various degrees of bleeding, ranging from mild to severe; however, adrenal haemorrhage due to LAHPS and its long-term clinical course have not been sufficiently described. Case presentation A 9-year-old boy presented with prolonged abdominal pain and abnormal coagulation screening tests. The laboratory tests showed prolonged activated partial thromboplastin time and subsequently revealed the presence of lupus anticoagulant, anti-nuclear antibodies, and hypoprothrombinemia, leading to diagnosis of LAHPS. An enhanced computed tomogram demonstrated nodular lesions in the adrenal glands bilaterally, suggestive of adrenal haemorrhage. Laboratory and clinical manifestations exhibited life-threatening adrenal insufficiency that required hydrocortisone administration. The patient developed systemic lupus erythematosus, diagnosed 12 months later. Conclusions This patient with LAHPS developed rare adrenal failure due to adrenal haemorrhage, a life-threatening event that should be recognized and treated early. In our case, renal dysfunction was also observed when systemic lupus erythematosus was diagnosed 1 year after LAHPS. Our case emphasizes that early recognition of adrenal failure and careful long-term observation is required in patients with autoantibodies.

Parenteral corticosteroids in emergency

1967 ◽  
Vol 5 (2) ◽  
pp. 6-7
Keyword(s):  
Oral Dose ◽  
Single Oral Dose ◽  
Corticosteroid Therapy ◽  
Plasma Concentrations ◽  
Addison’S Disease ◽  
Sudden Increase ◽  
Adrenal Failure ◽  
Intravenous Therapy ◽  
Intramuscular Dose ◽  
Acute Adrenal Failure

Corticosteroids are well absorbed from the gut: plasma concentrations of prednisolone or hydrocortisone are at a maximum about 2 hours after a single oral dose.1 An intramuscular dose acts no more quickly. Intravenous corticosteroid acts at once and is required for severe acute adrenal failure, for example in the crises of Addison’s disease, after adrenalectomy, after sudden cessation of corticosteroid therapy and sometimes in severe hypopituitarism. A sudden increase in the requirement of patients who are taking or have taken corticosteroids may also demand intravenous therapy.

scholarly journals Maternal Death Due to Acute Adrenal Failure and Myocarditis

BMJ ◽  
1962 ◽  
Vol 1 (5277) ◽  
pp. 526-527 ◽  
Author(s):  
S. Ende ◽  
G. M. Steiner
Keyword(s):  
Maternal Death ◽  
Adrenal Failure ◽  
Acute Adrenal Failure

scholarly journals Acute Adrenal Failure Associated with Primary Antiphospholipid Syndrome and Homozygosity for MTHFR C677T

2011 ◽  
Vol 50 (23) ◽  
pp. 2923-2926 ◽  
Author(s):  
Anastasios Mavridis ◽  
Marina Skopeliti ◽  
Panagiota Galani ◽  
Sofia Lafoyianni ◽  
Constantinos Christopoulos
Keyword(s):  
Antiphospholipid Syndrome ◽  
Mthfr C677t ◽  
Primary Antiphospholipid Syndrome ◽  
Adrenal Failure ◽  
Acute Adrenal Failure

scholarly journals Lupus Anticoagulant Hypoprothrombinemia Syndrome Associated with Bilateral Adrenal Hemorrhage in a Child: Early Diagnosis and Intervention

2020 ◽  
Author(s):  
Atsushi Sakamoto ◽  
Masao Ogura ◽  
Atsushi Hattori ◽  
Kinji Tada ◽  
Reiko Horikawa ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Lupus Anticoagulant ◽  
Early Recognition ◽  
Clinical Manifestations ◽  
Adrenal Hemorrhage ◽  
Screening Tests ◽  
Adrenal Failure ◽  
Systemic Lupus ◽  
Life Threatening

Abstract Background: Lupus anticoagulant-hypoprothrombinemia syndrome (LAHPS) is characterized by bleeding and thrombosis in patients, usually associated with autoimmunity or infections. Pediatric LAHPS exhibits various degrees of bleeding, ranging from mild to severe; however, adrenal hemorrhage due to LAHPS and its long-term clinical course have not been sufficiently described. Case presentation: A 9‐year‐old boy presented with prolonged abdominal pain and abnormal coagulation screening tests. The laboratory tests showed prolonged activated partial thromboplastin time and subsequently revealed the presence of lupus anticoagulant, anti-nuclear antibodies, and hypoprothrombinemia, leading to diagnosis of LAHPS. An enhanced computed tomogram demonstrated nodular lesions in the adrenal glands bilaterally, suggestive of adrenal hemorrhage. Laboratory and clinical manifestations exhibited life-threatening adrenal insufficiency that required hydrocortisone administration. The patient developed systemic lupus erythematosus, diagnosed 12 months later. Conclusions: The patient with LAHPS developed rare adrenal failure due to adrenal hemorrhage, a life-threatening event that should be recognized and treated early. In our case, renal dysfunction was also observed when systemic lupus erythematosus was diagnosed one year after LAHPS. Our case emphasizes that early recognition of adrenal failure and careful observation for patients with autoantibodies are required.

Disseminated Tuberculosis Causing Acute Adrenal Failure, C.T. Findings with Post Mortem Correlation

1988 ◽  
Vol 32 (3) ◽  
pp. 394-397 ◽  
Author(s):  
T.M. OSBORNE ◽  
M.J. SAGE
Keyword(s):  
Post Mortem ◽  
Adrenal Failure ◽  
Disseminated Tuberculosis ◽  
Acute Adrenal Failure

scholarly journals Acute adrenal failure

1980 ◽  
Vol 79 (6) ◽  
pp. 942
Author(s):  
Alan Gilston
Keyword(s):  
Adrenal Failure ◽  
Acute Adrenal Failure

Primary Antiphospholipid Syndrome Associated with Acute Adrenal Failure

2003 ◽  
Vol 325 (1) ◽  
pp. 41-44 ◽  
Author(s):  
K. Takebayashi ◽  
Y. Aso ◽  
K. Tayama ◽  
Y. Takemura ◽  
T. Inukai
Keyword(s):  
Antiphospholipid Syndrome ◽  
Primary Antiphospholipid Syndrome ◽  
Adrenal Failure ◽  
Acute Adrenal Failure
Sign in / Sign up

Export Citation Format

Share Document