Failure in Producing Antibodies of extra-agglutinin Character by intramuscular Injection of synthetic Vitamin K

Certain milk substitute infant formulas, particularly meat-based and casein hydrolysate based formulas, may be low in vitamin K content in relation to the needs of the infants receiving them. Studies are reviewed of a few infants in which inadequate dietary supply of vitamin K from such sources may have been one factor in the development of hypoprothrombinemia, though this could not be established with certainty. On theoretical grounds it seems reasonable to increase the level of vitamin K1 in milk substitute formulas to 100 µg/l, particularly because these products are often used in treatment of clinical conditions which are associated with diminished absorption of this vitamin. Vitamin K1 (phylloquinone) would seem the most appropriate form to be used for supplementation of formulas. In clinical situations associated with malabsorption of fat, e.g., cystic fibrosis of the pancreas or biliary atresia, and prolonged diarrhea or starvation, vitamin K supplementation of feedings or periodic parenteral administration of vitamin K is recommended. When parenteral vitamin K is necessary, intravenous administration is rarely indicated. Subcutaneous or intramuscular injection is preferred.

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Synthesis of Novel Synthetic Vitamin K Analogues Prepared by Introduction of a Heteroatom and a Phenyl Group That Induce Highly Selective Neuronal Differentiation of Neuronal Progenitor Cells

Journal of Medicinal Chemistry ◽

10.1021/acs.jmedchem.6b01717 ◽

2017 ◽

Vol 60 (6) ◽

pp. 2591-2596 ◽

Cited By ~ 10

Author(s):

Kimito Kimura ◽

Yoshihisa Hirota ◽

Shigefumi Kuwahara ◽

Atsuko Takeuchi ◽

Chisato Tode ◽

...

Keyword(s):

Progenitor Cells ◽

Neuronal Differentiation ◽

Vitamin K ◽

Phenyl Group ◽

Neuronal Progenitor Cells ◽

Neuronal Progenitor ◽

Synthetic Vitamin

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Vitamin K in pregnancy and breastfeeding

10.1093/med/9780198722700.003.0016 ◽

2015 ◽

Author(s):

Sir Peter Gluckman ◽

Mark Hanson ◽

Chong Yap Seng ◽

Anne Bardsley

Keyword(s):

Vitamin K ◽

Intracranial Haemorrhage ◽

Intramuscular Injection ◽

Blood Clotting ◽

Birth Trauma ◽

Vitamin K Deficiency ◽

Bleeding Events ◽

Term Neonates ◽

Risk Of Bleeding ◽

K Deficiency

Vitamin K is involved in blood clotting, and lack of this nutrient results in a hypocoagulable state, associated with a high risk of bleeding events. Deficiency is rare among adults, because vitamin K is widely available in foods. However, the placenta transmits vitamin K relatively poorly, leading to a general deficiency in full-term neonates, who are also particularly vulnerable to the effects of low vitamin K levels because of their immature clotting systems. Deficiency can lead to intracranial haemorrhage following birth trauma, or classic vitamin K deficiency bleeding. It is important to maintain adequate vitamin K status throughout pregnancy in order to avoid added risk to the neonate at birth and in the first few weeks of life. Supplementation of newborns by intramuscular injection should be universal.

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