Cutaneous Undifferentiated Small (Merkel) Cell Carcinoma, that Developed Synchronously with Multiple Actinic Keratoses, Squamous Cell Carcinomas and Basal Cell Carcinoma

2003 ◽  
Vol 30 (3) ◽  
pp. 241-244 ◽  
Author(s):  
Abdullah Aydin ◽  
N. Emrah Koçer ◽  
Mehmet Bekerecioğlu ◽  
Ibrahim Sari
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Squamous Cell ◽  
Basal Cell ◽  
Squamous Cell Carcinomas ◽  
Merkel Cell ◽  
Actinic Keratoses

scholarly journals Use of Ber-EP4 and Epithelial Specific Antigen to Differentiate Clinical Simulators of Basal Cell Carcinoma

2013 ◽  
Vol 5 ◽  
pp. BIC.S11856 ◽  
Author(s):  
Bahar Dasgeb ◽  
Tarana M Mohammadi ◽  
Darius R Mehregan
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Basal Cell ◽  
Specific Antigen ◽  
Squamous Cell Carcinomas ◽  
Positive Staining ◽  
Merkel Cell ◽  
Diagnostic Pitfall ◽  
Basal Cell Carcinomas

EpCam is a transmembrane epithelial adhesion molecule present on all non-squamous epithelial cells. It is often overexpressed in certain carcinomas, such as breast and colon, and in dermatology, eg, basal cell carcinoma (BCC). Various monoclonal antibodies have been used to detect EpCam, including BerEP4 and epithelial specific antigen. We compared anti-EpCam clones, BerEP4, and epithelial specific antigen clone VU-1D9. One hundred and twelve lesions were stained with both antibodies. All basal cell carcinomas stained uniformly and strongly positive with both antibodies. Diffuse positive staining was also seen in all trichoepitheliomas and merkel cell carcinomas. Focal positive staining was seen in squamous cell carcinoma and benign sebaceous neoplasms. Clone VU-1D9 was more likely to produce focal positive staining as compared to BerEP4. This focal positive staining of sebaceous neoplasms and squamous cell carcinomas is a potential diagnostic pitfall.

Emerging medical treatments for actinic keratoses, squamous cell carcinoma and basal cell carcinoma

2012 ◽  
Vol 2 (9) ◽  
pp. 909-921 ◽  
Author(s):  
Nasreen Ghuznavi ◽  
Nadia F Nocera ◽  
Andrew R Guajardo ◽  
Jeffrey M Weinberg
Keyword(s):  
Squamous Cell Carcinoma ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Basal Cell ◽  
Medical Treatments ◽  
Actinic Keratoses
Sign in / Sign up

Export Citation Format

Share Document