High fractional concentration of nitric oxide in exhaled air despite steroid treatment in asthmatic children

2005 ◽  
Vol 35 (7) ◽  
pp. 920-925 ◽  
Author(s):  
M. W. H. Pijnenburg ◽  
E. M. Bakker ◽  
S. Lever ◽  
W. C. Hop ◽  
J. C. De Jongste
2001 ◽  
Vol 91 (2) ◽  
pp. 703-708 ◽  
Author(s):  
C. Kotaru ◽  
M. Skowronski ◽  
A. Coreno ◽  
E. R. McFadden

To determine whether the inhibition of nitric oxide (NO) synthesis attenuates thermally induced obstruction, we had 10 asthmatic volunteers perform isocapnic hyperventilation with frigid air after inhaling 1 mg of N G-monomethyl-l-arginine (l-NMMA) or isotonic saline in a blinded fashion. The challenges were identical in all respects, and there were no differences in baseline lung function [1-s forced expiratory volume (FEV1); saline 2.8 ± 0.3 liters, l-NMMA 2.9 ± 0.3 liters; P = 0.41] or prechallenge fractional concentration of nitric oxide in the exhaled air (FeNO) [saline 23 ± 6 parts/billion (ppb),l-NMMA 18 ± 4 ppb; P = 0.51]. Neither treatment had any impact on the FEV1, pulse, or blood pressure. After l-NMMA, FeNO fell significantly ( P < 0.0001), the stimulus-response curves shifted to the right, and the minute ventilation required to reduce the FEV1 20% rose 53.5% over control ( P = 0.02). The results of this study demonstrate that NO generated from the airways of asthmatic individuals may play an important role in the pathogenesis of thermally induced asthma.


2013 ◽  
Vol 2013 (1) ◽  
pp. 4221
Author(s):  
Meryl Colton ◽  
Kanistha Chatterjee ◽  
Patrick Ryan ◽  
Yang Qiu ◽  
Tiina Reponen ◽  
...  

2009 ◽  
Vol 20 (2) ◽  
pp. 164-171 ◽  
Author(s):  
Massimo Pifferi ◽  
Vincenzo Ragazzo ◽  
Antonino Previti ◽  
Giovanni Pioggia ◽  
Marcello Ferro ◽  
...  

1997 ◽  
Vol 24 (5) ◽  
pp. 312-318 ◽  
Author(s):  
C. A. Byrnes ◽  
S. Dinarevic ◽  
E. A. Shinebourne ◽  
P. J. Barnes ◽  
A. Bush

Allergy ◽  
2005 ◽  
Vol 60 (11) ◽  
pp. 1436-1439 ◽  
Author(s):  
L. Mappa ◽  
F. Cardinale ◽  
R. Camodeca ◽  
M. L. Tortorella ◽  
A. Pietrobelli ◽  
...  

The Lancet ◽  
1966 ◽  
Vol 288 (7477) ◽  
pp. 1354-1356 ◽  
Author(s):  
N.M. Jacoby

2010 ◽  
Vol 153 (4) ◽  
pp. 403-412 ◽  
Author(s):  
Lars-Georg Hersoug ◽  
Lise Lotte N. Husemoen ◽  
Simon Francis Thomsen ◽  
Torben Sigsgaard ◽  
Betina H. Thuesen ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document