Hydroxyurea therapy increases plasma erythropoietin in patients with essential thrombocythaemia or polycythaemia vera

2006 ◽  
Vol 28 (4) ◽  
pp. 233-236 ◽  
Author(s):  
P. JOHANSSON ◽  
B. ANDRÉASSON
Keyword(s):  
Polycythaemia Vera ◽  
Essential Thrombocythaemia ◽  
Hydroxyurea Therapy

Epigenomic profiling in polycythaemia vera and essential thrombocythaemia shows low levels of aberrant DNA methylation

2011 ◽  
Vol 64 (11) ◽  
pp. 1010-1013 ◽  
Author(s):  
S. Barrio ◽  
M. Gallardo ◽  
E. Albizua ◽  
A. Jimenez ◽  
I. Rapado ◽  
...  
Keyword(s):  
Dna Methylation ◽  
Polycythaemia Vera ◽  
Essential Thrombocythaemia ◽  
Low Levels ◽  
Aberrant Dna Methylation

Thrombocytosis

2010 ◽  
pp. 4280-4287
Author(s):  
Stefan O. Ciurea ◽  
Ronald Hoffman
Keyword(s):  
Stem Cell ◽  
Platelet Count ◽  
Iron Deficiency ◽  
Blood Loss ◽  
Haematopoietic Stem Cell ◽  
Polycythaemia Vera ◽  
Essential Thrombocythaemia ◽  
Platelet Production ◽  
The Many ◽  
Different Levels

Thrombocytosis describes a platelet count elevated above 450 × 109/litre, which can be (1) primary—including essential thrombocythaemia, chronic myeloid leukaemia, polycythaemia vera and myelodysplastic syndromes; or (2) secondary—including iron deficiency, infection, blood loss, malignancy. Platelets are released from megakaryocytes, whose development is principally regulated by thrombopoietin. This is chiefly produced in the liver and binds to its receptor (c-Mpl) to cause activation via the JAK-STAT signalling pathway at different levels of the platelet production pathway, ranging from the proliferation and survival of haematopoietic stem cell/progenitor cells to megakaryocyte maturation. Thrombopoietin production is increased by a wide variety of stimuli, which explains the many causes of secondary thrombocytosis....

Long-Term Bone Marrow Cultures in Polycythaemia vera and Essential Thrombocythaemia

1996 ◽  
Vol 96 (4) ◽  
pp. 227-231 ◽  
Author(s):  
Riitta Jantunen ◽  
Eeva Juvonen ◽  
Ari Aimolahti ◽  
Tapani Ruutu
Keyword(s):  
Bone Marrow ◽  
Polycythaemia Vera ◽  
Essential Thrombocythaemia ◽  
Bone Marrow Cultures ◽  
Marrow Cultures

Polycythaemia Vera and Essential Thrombocythaemia in the Elderly

Drugs & Aging ◽  
2000 ◽  
Vol 17 (2) ◽  
pp. 107-119 ◽  
Author(s):  
Perry J.J. van Genderen ◽  
Monique M. Troost
Keyword(s):  
The Elderly ◽  
Polycythaemia Vera ◽  
Essential Thrombocythaemia

JAK2V617F mutation and spontaneous megakaryocytic or erythroid colony formation in patients with essential thrombocythaemia (ET) or polycythaemia vera (PV)

2009 ◽  
Vol 33 (1) ◽  
pp. 54-59 ◽  
Author(s):  
Satu Mustjoki ◽  
Ioana Borze ◽  
Terra L. Lasho ◽  
Riitta Alitalo ◽  
Animesh Pardanani ◽  
...  
Keyword(s):  
Colony Formation ◽  
Jak2v617f Mutation ◽  
Polycythaemia Vera ◽  
Essential Thrombocythaemia

Open-label study of oral CEP-701 (lestaurtinib) in patients with polycythaemia vera or essential thrombocythaemia withJAK2-V617F mutation

2013 ◽  
Vol 164 (1) ◽  
pp. 83-93 ◽  
Author(s):  
Elizabeth Hexner ◽  
Gail Roboz ◽  
Ron Hoffman ◽  
Selina Luger ◽  
John Mascarenhas ◽  
...  
Keyword(s):  
Polycythaemia Vera ◽  
Essential Thrombocythaemia ◽  
Open Label ◽  
Open Label Study ◽  
Label Study ◽  
V617f Mutation
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