scholarly journals Rift Valley fever in West Africa: the role of space in endemicity

2006 ◽  
Vol 11 (12) ◽  
pp. 1878-1888 ◽  
Author(s):  
Charly Favier ◽  
Karine Chalvet-Monfray ◽  
Philippe Sabatier ◽  
Renaud Lancelot ◽  
Didier Fontenille ◽  
...  
Keyword(s):  
West Africa ◽  
Rift Valley ◽  
Rift Valley Fever ◽  
Valley Fever

scholarly journals The S Segment of Rift Valley Fever Phlebovirus (Bunyaviridae) Carries Determinants for Attenuation and Virulence in Mice

2000 ◽  
Vol 74 (3) ◽  
pp. 1538-1543 ◽  
Author(s):  
P. Vialat ◽  
A. Billecocq ◽  
A. Kohl ◽  
M. Bouloy
Keyword(s):  
Rift Valley ◽  
Rift Valley Fever ◽  
Nonstructural Protein ◽  
Rift Valley Fever Virus ◽  
Virulent Strain ◽  
Coding Region ◽  
Valley Fever ◽  
Attenuated Virus ◽  
Infected Cells

ABSTRACT Unlike all the other Rift Valley fever virus strains (Bunyaviridae, Phlebovirus) studied so far, clone 13, a naturally attenuated virus, does not form the filaments composed of the NSs nonstructural protein in the nuclei of infected cells (R. Muller, J. F. Saluzzo, N. Lopez, T. Drier, M. Turell, J. Smith, and M. Bouloy, Am. J. Trop. Med. Hyg. 53:405–411, 1995). This defect is correlated with a large in-frame deletion in the NSs coding region of the S segment of the tripartite genome. Here, we show that the truncated NSs protein of clone 13 is expressed and remains in the cytoplasm, where it is degraded rapidly by the proteasome. Through the analysis of reassortants between clone 13 and a virulent strain, we localized the marker(s) of attenuation in the S segment of this attenuated virus. This result raises questions regarding the role of NSs in pathogenesis and highlights, for the first time in theBunyaviridae family, a major role of the S segment in virulence and attenuation, possibly associated with a defect in the nonstructural protein.

scholarly journals Role of the cytosolic tails of Rift Valley fever virus envelope glycoproteins in viral morphogenesis

Virology ◽  
2014 ◽  
Vol 448 ◽  
pp. 1-14 ◽  
Author(s):  
Xavier Carnec ◽  
Myriam Ermonval ◽  
Felix Kreher ◽  
Marie Flamand ◽  
Michèle Bouloy
Keyword(s):  
Rift Valley ◽  
Rift Valley Fever ◽  
Rift Valley Fever Virus ◽  
Fever Virus ◽  
Envelope Glycoproteins ◽  
Virus Envelope ◽  
Valley Fever ◽  
Viral Morphogenesis

THE ROLE OF WILD MAMMALS IN THE MAINTENANCE OF RIFT VALLEY FEVER VIRUS

2012 ◽  
Vol 48 (2) ◽  
pp. 241-266 ◽  
Author(s):  
Marie-Marie Olive ◽  
Steven M. Goodman ◽  
Jean-Marc Reynes
Keyword(s):  
Rift Valley ◽  
Rift Valley Fever ◽  
Rift Valley Fever Virus ◽  
Fever Virus ◽  
Valley Fever ◽  
Wild Mammals

The potential role of rodents in the enzootic cycle of Rift Valley fever virus in Senegal

2000 ◽  
Vol 2 (4) ◽  
pp. 343-346 ◽  
Author(s):  
Diop Gora ◽  
Thiongane Yaya ◽  
Thonnon Jocelyn ◽  
Fontenille Didier ◽  
Diallo Maoulouth ◽  
...  
Keyword(s):  
Rift Valley ◽  
Rift Valley Fever ◽  
Potential Role ◽  
Rift Valley Fever Virus ◽  
Fever Virus ◽  
Valley Fever ◽  
Enzootic Cycle
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