Synthesis of thymosin α1 by fragment condensation using tert.-butyl side chain protection

2009 ◽  
Vol 26 (2) ◽  
pp. 130-148 ◽  
Author(s):  
ARTHUR M. FELIX ◽  
EDGAR P. HEIMER ◽  
CHING-TSO WANG ◽  
THEODORE J. LAMBROS ◽  
JOSEPH SWISTOK ◽  
...  
Keyword(s):  
Side Chain ◽  
Thymosin Α1 ◽  
Tert Butyl ◽  
Fragment Condensation

scholarly journals Phenylthiazoles with tert-Butyl side chain: Metabolically stable with anti-biofilm activity

2018 ◽  
Vol 151 ◽  
pp. 110-120 ◽  
Author(s):  
Ahmed Kotb ◽  
Nader S. Abutaleb ◽  
Mohamed A. Seleem ◽  
Mohamed Hagras ◽  
Haroon Mohammad ◽  
...  
Keyword(s):  
Side Chain ◽  
Tert Butyl

The tert-Butyl Side Chain: A Powerful Means to Lock Peptoid Amide Bonds in the Cis Conformation

2013 ◽  
Vol 15 (9) ◽  
pp. 2246-2249 ◽  
Author(s):  
O. Roy ◽  
C. Caumes ◽  
Y. Esvan ◽  
C. Didierjean ◽  
S. Faure ◽  
...  
Keyword(s):  
Side Chain ◽  
Amide Bonds ◽  
Tert Butyl ◽  
Powerful Means

PREPARATION AND PROPERTIES OF Nα-9-FLUORENYLMETHYLOXYCARBONYLAMINO ACIDS BEARING TERT.-BUTYL SIDE CHAIN PROTECTION

2009 ◽  
Vol 15 (1) ◽  
pp. 59-66 ◽  
Author(s):  
CHI-DEU CHANG ◽  
MICHINORI WAKI ◽  
MUSHTAQ AHMAD ◽  
JOHANNES MEIENHOFER ◽  
EDWIN O. LUNDELL ◽  
...  
Keyword(s):  
Side Chain ◽  
Tert Butyl

Synthesis of the major encephalitogenic determinant of myelin basic protein and the 13C N.M.R. of some protected intermediates

1977 ◽  
Vol 30 (11) ◽  
pp. 2533 ◽  
Author(s):  
SJ Pasaribu
Keyword(s):  
Myelin Basic Protein ◽  
Catalytic Hydrogenation ◽  
Basic Protein ◽  
Side Chain ◽  
Benzyl Ether ◽  
Protecting Group ◽  
Fragment Condensation

The main encephalitogenic determinant of bovine myelin basic protein (MBP 114-122) has been synthesized through fragment condensation of tetrapeptide, Boc-Phe-Ser-Trp-Gly-OH, and penta-peptide, H-Ala- Glu(OBzl)-Gly-Gln-Lys(Nε-Cbz)-Obzl. It was observed that the benzyl ether protecting group of the serine side chain was not removed during catalytic hydrogenation (Pd/C-H2) of the tetrapeptide, Boc-Phe- Ser(OBzl)-Trp-Gly-OBzl. 13C N.M.R. spectra of some other intermediates are discussed.

Synthesis and properties of oxytocin analogues modified in the tripeptide side chain

1984 ◽  
Vol 49 (3) ◽  
pp. 642-652 ◽  
Author(s):  
Zdenko Procházka ◽  
Michal Lebl ◽  
Tomislav Barth ◽  
Jan Hlaváček ◽  
Antonín Trka ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
Carboxylic Acid ◽  
Biological Activities ◽  
The Other ◽  
Side Chain ◽  
H Nmr ◽  
Fragment Condensation

Two oxytocin analogues were synthesized by fragment condensation (6 + 3) in the presence of dicyclohexylcarbodiimide and 1-hydroxybenzotriazole. In one of the analogues, proline in the position 7 and leucine in the position 8 were substituted by 2-[1-(2-oxo-3-aminopyrrolidinyl)]-4-methylpentanoic acid, in the other proline was replaced by 1-aminocyclopropane-1-carboxylic acid. Biological activities of the first analogue were strongly reduced and dissociation of the uterotonic and galoctogogic activities was observed with both the analogues. The structure of 2-(3-tert-butyloxycarbonylaminopyrrolidin-2-on-1-yl)-4-methylpentanoylglycine and its amide was confirmed by mass and 1 H NMR spectroscopy.

Synthese eines Thymosin β10-Fragments zur Entwicklung spezifischer Antikörper / Synthesis of a Fragment of Thymosin β10 for the Development of Specific Antibodies

1992 ◽  
Vol 47 (8) ◽  
pp. 1170-1174 ◽  
Author(s):  
Susanne Hörger ◽  
Brigitte Gallert ◽  
Hartmut Echner ◽  
Wolfgang Voelter
Keyword(s):  
Amino Acids ◽  
Solid Phase ◽  
Protecting Groups ◽  
Side Chain ◽  
Phase Method ◽  
Preparative Hplc ◽  
Specific Antibodies ◽  
Tert Butyl ◽  
Thymosin Β10 ◽  
Solid Phase Method

The N-terminal fragment 1-12 of thymosin β10 was synthesized by the solid phase method using p-benzyloxybenzyl alcohol/polystyrene/divinylbenzeneresin and N-a-Fmoc amino acids with tert-butyl or Boc side chain protecting groups. Coupling was performed with BOP. The peptide was purified by preparative HPLC.

Synthesis of Monofunctionalized Calix[5]arenes

Synthesis ◽  
2017 ◽  
Vol 50 (03) ◽  
pp. 676-684 ◽  
Author(s):  
Arne Lützen ◽  
Björn Ingenfeld ◽  
Steffen Straub ◽  
Christopher Frömbgen
Keyword(s):  
Hydrogen Bonds ◽  
Functional Groups ◽  
Functional Group ◽  
Building Blocks ◽  
Cone Conformation ◽  
Oh Groups ◽  
Tert Butyl ◽  
Fragment Condensation ◽  
Molecular Architectures ◽  
Phenolic Oh Groups

Seven OH-free and O-permethylated monofunctionalized calix[5]arenes carrying either additional methyl or tert-butyl groups are prepared following fragment condensation protocols. This strategy proves to be superior to previous approaches. Calix[5]arenes with free OH groups all adopt a cone conformation stabilized by a seam of hydrogen bonds at the lower rim. Post-condensation modifications, i.e., methylation of phenolic OH groups or functional group interconversions can also be achieved. Bulky tert-butyl groups are also found to stabilize the cone conformations of O-methylated compounds. These compounds offer versatile functional groups that make these concave molecules interesting building blocks for the synthesis of more sophisticated molecular architectures.

Development of a Practical, Biocatalytic Synthesis of tert-Butyl (R)-3-Hydroxyl-5-hexenoate: A Key Intermediate to the Statin Side Chain

2020 ◽  
Vol 24 (9) ◽  
pp. 1700-1706
Author(s):  
Chen Hu ◽  
Minjie Liu ◽  
Xiaoping Yue ◽  
Zedu Huang ◽  
Fener Chen
Keyword(s):  
Side Chain ◽  
Tert Butyl
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