Increased Ig-null B lymphocytes in the peripheral blood of pediatric solid organ transplant recipients with elevated Epstein-Barr viral loads

2009 ◽  
Vol 13 (3) ◽  
pp. 311-318 ◽  
Author(s):  
Elizabeth Schauer ◽  
Steven Webber ◽  
Laurence Kingsley ◽  
Michael Green ◽  
David Rowe
Keyword(s):  
B Lymphocytes ◽  
Peripheral Blood ◽  
Organ Transplant ◽  
Solid Organ Transplant ◽  
Solid Organ ◽  
Transplant Recipients ◽  
Organ Transplant Recipients ◽  
Viral Loads ◽  
Solid Organ Transplant Recipients ◽  
Epstein Barr

scholarly journals Detection of Epstein-Barr Virus DNA in Sera from Transplant Recipients with Lymphoproliferative Disorders

1999 ◽  
Vol 37 (4) ◽  
pp. 1113-1116 ◽  
Author(s):  
Ajit P. Limaye ◽  
Meei-Li Huang ◽  
Ederlyn E. Atienza ◽  
James M. Ferrenberg ◽  
Lawrence Corey
Keyword(s):  
Epstein Barr Virus ◽  
Organ Transplant ◽  
Solid Organ Transplant ◽  
Solid Organ ◽  
Transplant Recipients ◽  
Organ Transplant Recipients ◽  
Barr Virus ◽  
Ebv Dna ◽  
Solid Organ Transplant Recipients ◽  
Epstein Barr

Early diagnosis of Epstein-Barr Virus (EBV)-associated posttransplant lymphoproliferative disease (PTLD) is important because many patients respond to reduction in immunosuppression, especially if PTLD is detected at an early stage. Previous studies have found elevated EBV DNA levels in blood from patients with PTLD, but these assays required isolation of cellular blood fractions and quantitation. We evaluated the presence of cell-free EBV DNA in serum from solid-organ transplant recipients as a marker for PTLD. Five of 6 transplant recipients with histopathologically documented PTLD had EBV DNA detected in serum at the time of diagnosis (sensitivity = 83%), compared with 0 of 16 matched transplant recipients without PTLD (specificity = 100%) (P < 0.001 [Fisher’s exact test]). Furthermore, EBV DNA was detected in serum 8 and 52 months prior to the diagnosis of PTLD in two of three patients for whom stored sera were analyzed. Detection of EBV DNA in serum appears to be a useful marker for the early detection of PTLD in solid-organ transplant recipients. Further studies to define the role of such assays in evaluating solid-organ transplant patients at risk for PTLD are warranted.

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