scholarly journals Use of monoclonal antibodies to study the structure and function of eukaryotic protein synthesis initiation factor eIF-2B

1994 ◽  
Vol 221 (1) ◽  
pp. 399-410 ◽  
Author(s):  
Susan OLDFIELD ◽  
Bridget L. JONES ◽  
Deborah TANTON ◽  
Christopher G. PROUD
Keyword(s):  
Protein Synthesis ◽  
Monoclonal Antibodies ◽  
Structure And Function ◽  
Initiation Factor ◽  
Eukaryotic Protein ◽  
Protein Synthesis Initiation ◽  
And Function

eIF2B, a mediator of general and gene-specific translational control

2005 ◽  
Vol 33 (6) ◽  
pp. 1487-1492 ◽  
Author(s):  
G.D. Pavitt
Keyword(s):  
Translational Control ◽  
Biochemical Analysis ◽  
Molecular Genetic ◽  
Structure And Function ◽  
Initiation Factor ◽  
Protein Synthesis Initiation ◽  
Vanishing White Matter Disease ◽  
And Function ◽  
Vanishing White Matter ◽  
Childhood Ataxia

eIF2B (eukaryotic initiation factor 2B) is a multisubunit protein that is required for protein synthesis initiation and its regulation in all eukaryotic cells. Mutations in eIF2B have also recently been found to cause a fatal human disease called CACH (childhood ataxia with central nervous system hypomyelination) or VWM (vanishing white matter disease). This review provides a general background to translation initiation and mechanisms known to control eIF2B function, before describing molecular genetic and biochemical analysis of eIF2B structure and function, integrating work from studies of the yeast and mammalian eIF2B proteins.

scholarly journals The Soy Isoflavone Equol May Increase Cancer Malignancy via Up-regulation of Eukaryotic Protein Synthesis Initiation Factor eIF4G

2012 ◽  
Vol 287 (50) ◽  
pp. 41640-41650 ◽  
Author(s):  
Columba de la Parra ◽  
Elisa Otero-Franqui ◽  
Michelle Martinez-Montemayor ◽  
Suranganie Dharmawardhane
Keyword(s):  
Protein Synthesis ◽  
Initiation Factor ◽  
Soy Isoflavone ◽  
Eukaryotic Protein ◽  
Protein Synthesis Initiation
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