ROLE OF THE MESOLIMBIC DOPAMINE SYSTEM IN CARDIOVASCULAR HOMEOSTASIS. STIMULATION OF THE VENTRAL TEGMENTAL AREA MODULATES THE EFFECT OF VASOPRESSIN ON BLOOD PRESSURE IN CONSCIOUS RATS

1998 ◽  
Vol 25 (9) ◽  
pp. 661-668 ◽  
Author(s):  
Maarten Buuse
Keyword(s):  
Blood Pressure ◽  
Ventral Tegmental Area ◽  
Mesolimbic Dopamine ◽  
Dopamine System ◽  
Mesolimbic Dopamine System ◽  
Conscious Rats ◽  
Ventral Tegmental ◽  
Cardiovascular Homeostasis ◽  
Stimulation Of

scholarly journals The mesolimbic dopamine signatures of relapse to alcohol-seeking

2020 ◽  
Author(s):  
Yu Liu ◽  
Philip Jean-Richard-dit-Bressel ◽  
Joanna Oi-Yue Yau ◽  
Alexandra Willing ◽  
Asheeta A. Prasad ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Ventral Tegmental Area ◽  
Activity Patterns ◽  
Mesolimbic Dopamine ◽  
Self Administration ◽  
Dopamine System ◽  
Mesolimbic Dopamine System ◽  
Ventral Tegmental ◽  
Alcohol Seeking

AbstractThe mesolimbic dopamine system comprises distinct compartments supporting different functions in learning and motivation. Less well understood is how complex addiction-related behaviors emerge from activity patterns across these compartments. Here we show how different forms of relapse to alcohol-seeking are assembled from activity across the ventral tegmental area and the nucleus accumbens. Using gCaMP and dLight fibre photometry, we show that self-administration and two forms of relapse (renewal/context-induced reinstatement and reacquisition) are associated with recruitment across the mesolimbic dopamine system. Using a variety of interventions, we show that this activity is causal to both forms of relapse. Finally, we use dissimilarity matrices to identify mesolimbic dopamine signatures of self-administration, extinction, and relapse. We show that signatures of relapse can be identified from heterogeneous activity profiles across the mesolimbic dopamine system and that these signatures differ for different forms of relapse.

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