Goodpasture's disease: Antiglomerular basement membrane disease

Nephrology ◽  
2004 ◽  
Vol 9 (2) ◽  
pp. 49-51 ◽  
Author(s):  
JONATHAN H ERLICH ◽  
JACOB SEVASTOS ◽  
BRUCE A PUSSELL
2018 ◽  
Vol 90 (6) ◽  
pp. 130-136 ◽  
Author(s):  
M L Bulanova ◽  
D V Potapov ◽  
N M Bulanov ◽  
L V Lysenko(Kozlovskaya)

Goodpasture’s disease (anti-GBM disease) is a rare small vessels vasculitis characterized by the presence of autoantibodies directed against the glomerular basement membrane (GBM) and alveolar basement membrane. Common feature of anti-GBM disease is a combination of rapidly progressive glomerulonephritis and alveolar hemorrhage (pulmonary-renal syndrome). We present a case of atypical disease course in a young male patient who developed alveolar hemorrhage without renal failure. The only symptom of renal involvement was isolated hematuria. Plasmapheresis combined with immunosuppression (cyclophosphamide and corticosteroids) was effective. We present a review of state-of-art data on the pathogenesis and disease course of anti-GBM disease.


Author(s):  
Jeremy Levy ◽  
Charles Pusey

Antiglomerular basement membrane disease (anti-GBM disease, also known as Goodpasture’s disease) is a rare autoimmune disease caused by pathogenic autoantibodies directed against the noncollagenous, C-terminal domain of the α‎-3 chain of type IV collagen (α‎3(IV)NC1). Immunohistology is characteristic, with linear deposition of IgG (sometimes with IgA or IgM) and complement C3 along the GBMs....


2002 ◽  
Vol 39 (6) ◽  
pp. 1162-1167 ◽  
Author(s):  
Alan D. Salama ◽  
Tammy Dougan ◽  
Jeremy B. Levy ◽  
H.Terry Cook ◽  
Steve H. Morgan ◽  
...  

2018 ◽  
Vol 6 (2) ◽  
Author(s):  
Elena V Zakharova ◽  
Tatyana A Makarova ◽  
Zhanna V Sheikh ◽  
Hadyja M Emirova ◽  
Ekaterina S Stolyarevich

2013 ◽  
Vol 12 (11) ◽  
pp. 1101-1108 ◽  
Author(s):  
Franco Dammacco ◽  
Stefano Battaglia ◽  
Loreto Gesualdo ◽  
Vito Racanelli

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