Canagliflozin, a novel inhibitor of sodium glucose co-transporter 2, dose dependently reduces calculated renal threshold for glucose excretion and increases urinary glucose excretion in healthy subjects

2011 ◽  
Vol 13 (7) ◽  
pp. 669-672 ◽  
Author(s):  
S. Sha ◽  
D. Devineni ◽  
A. Ghosh ◽  
D. Polidori ◽  
S. Chien ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Urinary Glucose Excretion ◽  
Renal Threshold ◽  
Urinary Glucose ◽  
Glucose Excretion

Dapagliflozin twice daily or once daily: effect on pharmacokinetics and urinary glucose excretion in healthy subjects

2015 ◽  
Vol 17 (4) ◽  
pp. 423-425 ◽  
Author(s):  
W. Tang ◽  
S. Reele ◽  
J. E. Hamer-Maansson ◽  
S. Parikh ◽  
T. W. A. de Bruin
Keyword(s):  
Healthy Subjects ◽  
Urinary Glucose Excretion ◽  
Once Daily ◽  
Urinary Glucose ◽  
Glucose Excretion

155-LB: The Increase in Endogenous Glucose Production with SGLT2 Inhibition Is Unchanged by Renal Denervation but Highly Correlates to Urinary Glucose Excretion

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 155-LB
Author(s):  
CAROLINA SOLIS-HERRERA ◽  
MARIAM ALATRACH ◽  
CHRISTINA AGYIN ◽  
HENRI HONKA ◽  
RUPAL PATEL ◽  
...  
Keyword(s):  
Renal Denervation ◽  
Glucose Production ◽  
Endogenous Glucose Production ◽  
Urinary Glucose Excretion ◽  
Urinary Glucose ◽  
Sglt2 Inhibition ◽  
Endogenous Glucose ◽  
Glucose Excretion

scholarly journals Morning Spot Urine Glucose-to-Creatinine Ratios Predict Overnight Urinary Glucose Excretion in Patients With Type 2 Diabetes

2017 ◽  
Vol 37 (1) ◽  
pp. 9-17 ◽  
Author(s):  
So Ra Kim ◽  
Yong-ho Lee ◽  
Sang-Guk Lee ◽  
Sun Hee Lee ◽  
Eun Seok Kang ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Urinary Glucose Excretion ◽  
Urine Glucose ◽  
Spot Urine ◽  
Urinary Glucose ◽  
Glucose Excretion

Abnormal renal glucose handling in X-linked hypophosphataemic mice

1991 ◽  
Vol 80 (1) ◽  
pp. 71-76 ◽  
Author(s):  
R. C. Mühlbauer ◽  
H. Fleisch
Keyword(s):  
Plasma Glucose ◽  
Glucose Concentration ◽  
Plasma Glucose Concentration ◽  
Urinary Glucose Excretion ◽  
Renal Handling ◽  
Acute Response ◽  
Altered Glucose ◽  
Urinary Glucose ◽  
Glucagon And Insulin ◽  
Glucose Excretion

1. The renal handling of glucose was determined in male X-linked hypophosphataemic (Hyp/Y) mice and in control littermates (+/Y) aged 4 months. Plasma glucose concentration and urinary glucose excretion were measured before and during stepwise increase in glycaemia induced by an acute infusion of glucose. The relationship between plasma glucose concentration and urinary glucose excretion was monitored per ml of glomerular filtrate in mice fed high and low phosphate diets. 2. Hyp/Y mice fed the high phosphate diet showed a significantly higher glucosuria compared with +/Y littermates. When glycaemia was increased, Hyp/Y mice developed frank glucosuria earlier than +/Y animals. In Hyp/Y mice we could not find a threshold below which virtually no glucose was excreted in the urine, whereas this was clearly visible in +/Y mice. These differences persisted in animals fed the low phosphate diet. 3. Using the acute response to the glucoregulatory hormones, glucagon and insulin, administered exogenously, we found that the regulation of plasma glucose concentration did not differ between Hyp/Y and +/Y mice. 4. The significantly lower plasma glucose concentration observed in Hyp/Y as compared with +/Y mice decreased further during fasting. 5. We conclude that the renal reabsorptive capacity for glucose is defective in Hyp/Y mice and their low plasma glucose concentration may be explained by the renal leak. Therefore the X-linked phosphataemic mouse appears not only to be characterized by a defect in renal phosphate and calcium reabsorption but also by an altered glucose reabsorption.

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