Cardiovascular benefits beyond urinary glucose excretion: a hypothesis generated from two meta‐analyses

2021 ◽  
Author(s):  
Chu Lin ◽  
Xiaoling Cai ◽  
J Linong
Keyword(s):  
Urinary Glucose Excretion ◽  
Urinary Glucose ◽  
Meta Analyses ◽  
Glucose Excretion

155-LB: The Increase in Endogenous Glucose Production with SGLT2 Inhibition Is Unchanged by Renal Denervation but Highly Correlates to Urinary Glucose Excretion

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 155-LB
Author(s):  
CAROLINA SOLIS-HERRERA ◽  
MARIAM ALATRACH ◽  
CHRISTINA AGYIN ◽  
HENRI HONKA ◽  
RUPAL PATEL ◽  
...  
Keyword(s):  
Renal Denervation ◽  
Glucose Production ◽  
Endogenous Glucose Production ◽  
Urinary Glucose Excretion ◽  
Urinary Glucose ◽  
Sglt2 Inhibition ◽  
Endogenous Glucose ◽  
Glucose Excretion

scholarly journals Morning Spot Urine Glucose-to-Creatinine Ratios Predict Overnight Urinary Glucose Excretion in Patients With Type 2 Diabetes

2017 ◽  
Vol 37 (1) ◽  
pp. 9-17 ◽  
Author(s):  
So Ra Kim ◽  
Yong-ho Lee ◽  
Sang-Guk Lee ◽  
Sun Hee Lee ◽  
Eun Seok Kang ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Urinary Glucose Excretion ◽  
Urine Glucose ◽  
Spot Urine ◽  
Urinary Glucose ◽  
Glucose Excretion

Abnormal renal glucose handling in X-linked hypophosphataemic mice

1991 ◽  
Vol 80 (1) ◽  
pp. 71-76 ◽  
Author(s):  
R. C. Mühlbauer ◽  
H. Fleisch
Keyword(s):  
Plasma Glucose ◽  
Glucose Concentration ◽  
Plasma Glucose Concentration ◽  
Urinary Glucose Excretion ◽  
Renal Handling ◽  
Acute Response ◽  
Altered Glucose ◽  
Urinary Glucose ◽  
Glucagon And Insulin ◽  
Glucose Excretion

1. The renal handling of glucose was determined in male X-linked hypophosphataemic (Hyp/Y) mice and in control littermates (+/Y) aged 4 months. Plasma glucose concentration and urinary glucose excretion were measured before and during stepwise increase in glycaemia induced by an acute infusion of glucose. The relationship between plasma glucose concentration and urinary glucose excretion was monitored per ml of glomerular filtrate in mice fed high and low phosphate diets. 2. Hyp/Y mice fed the high phosphate diet showed a significantly higher glucosuria compared with +/Y littermates. When glycaemia was increased, Hyp/Y mice developed frank glucosuria earlier than +/Y animals. In Hyp/Y mice we could not find a threshold below which virtually no glucose was excreted in the urine, whereas this was clearly visible in +/Y mice. These differences persisted in animals fed the low phosphate diet. 3. Using the acute response to the glucoregulatory hormones, glucagon and insulin, administered exogenously, we found that the regulation of plasma glucose concentration did not differ between Hyp/Y and +/Y mice. 4. The significantly lower plasma glucose concentration observed in Hyp/Y as compared with +/Y mice decreased further during fasting. 5. We conclude that the renal reabsorptive capacity for glucose is defective in Hyp/Y mice and their low plasma glucose concentration may be explained by the renal leak. Therefore the X-linked phosphataemic mouse appears not only to be characterized by a defect in renal phosphate and calcium reabsorption but also by an altered glucose reabsorption.

scholarly journals Increase in Endogenous Glucose Production With SGLT2 Inhibition Is Unchanged by Renal Denervation and Correlates Strongly With the Increase in Urinary Glucose Excretion

Diabetes Care ◽  
2020 ◽  
Vol 43 (5) ◽  
pp. 1065-1069 ◽  
Author(s):  
Carolina Solis-Herrera ◽  
Giuseppe Daniele ◽  
Mariam Alatrach ◽  
Christina Agyin ◽  
Curtis Triplitt ◽  
...  
Keyword(s):  
Renal Denervation ◽  
Glucose Production ◽  
Endogenous Glucose Production ◽  
Urinary Glucose Excretion ◽  
Urinary Glucose ◽  
Sglt2 Inhibition ◽  
Endogenous Glucose ◽  
Glucose Excretion

Acute glucocorticoid treatment increases urinary biotin excretion and serum biotin

2002 ◽  
Vol 282 (3) ◽  
pp. E643-E649 ◽  
Author(s):  
Sara C. Rathman ◽  
Brandon Lewis ◽  
Robert J. McMahon
Keyword(s):  
Chronic Administration ◽  
Experimental Models ◽  
Acute Administration ◽  
Urinary Glucose Excretion ◽  
Glucocorticoid Treatment ◽  
Physiological Level ◽  
Regulatory Pathways ◽  
Urinary Glucose ◽  
Glucose Output ◽  
Glucose Excretion

Previous studies have demonstrated that glucocorticoids alter biotin metabolism. To extend these studies, the effect of dexamethasone on biotin pools was analyzed in rats consuming a purified diet containing a more physiological level of dietary biotin intake (0.06 mg/kg). Acute (5 h) dexamethasone administration (0.5 mg/kg) elicited elevated urinary glucose output as well as elevated urinary biotin excretion and serum biotin. Renal and hepatic free biotin was also significantly elevated by acute dexamethasone administration. Chow-fed rats treated with an acute administration of dexamethasone demonstrated significantly elevated urinary glucose excretion, urinary biotin excretion, and serum biotin, but no change in tissue associated biotin was detected. Chronic administration of dexamethasone (0.5 mg/kg ip) over 4 days significantly elevated urinary glucose excretion 42% but had no effect on urinary biotin excretion, serum biotin, or hepatic- or renal-associated free biotin. These results demonstrate the existence of potentially novel regulatory pathways for total biotin pools and the possibility that experimental models with high initial biotin status may mask potentially important regulatory mechanisms.

scholarly journals Clinical and genetic determinants of urinary glucose excretion in patients with diabetes mellitus

2020 ◽  
Author(s):  
Keisuke Monobe ◽  
Shinsuke Noso ◽  
Naru Babaya ◽  
Yoshihisa Hiromine ◽  
Yasunori Taketomo ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Genetic Determinants ◽  
Urinary Glucose Excretion ◽  
Urinary Glucose ◽  
Patients With Diabetes ◽  
Glucose Excretion
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