Isolation and Immunohistochemical Localization of a Chondroitin Sulfate Proteoglycan from Adult Rat Brain

1988 ◽  
Vol 51 (3) ◽  
pp. 665-676 ◽  
Author(s):  
Guy Normand ◽  
Sabine Kuchler ◽  
Alphonse Meyer ◽  
Guy Vincendon ◽  
Jean-Pierre Zanetta
2008 ◽  
Vol 60 (4) ◽  
pp. 581-591
Author(s):  
Sanja Dacic ◽  
Sanja Pekovic ◽  
Maja Stojiljkovic ◽  
Irena Lavrnja ◽  
Danijela Stojkov ◽  
...  

The central nervous system has a limited capacity for self-repair after damage. However, the neonatal brain has agreater capacity for recovery than the adult brain. These differences in the regenerative capability depend on local environmental factors and the maturational stage of growing axons. Among molecules which have both growth-promoting and growth-inhibiting activities is the heterogeneous class of chondroitin sulfate proteoglycans (CSPGs). In this paper, we investigated the chondroitin-4 and chondroitin-6 sulfate proteoglycan expression profile after left sensorimotor cortex ablation of the neonatal and adult rat brain. Immunohistochemical analysis revealed that compared to the normal uninjured cortex, lesion provoked up regulation of CSPGs showing a different pattern of expression in the neonatal vs. the adult brain. Punctuate and membrane-bound labeling was predominate after neonatal lesion, where as heavy deposition of staining in the extracellular matrix was observed after adult lesion. Heavy deposition of CSPG immunoreactivity around the lesionsite in adult rats, in contrast to a less CSPG-rich environment in neonatal rats, indicated that enhancement of the recovery process after neonatal injury is due to amore permissive environment.


1995 ◽  
Vol 270 (45) ◽  
pp. 27206-27212 ◽  
Author(s):  
Constanze I. Seidenbecher ◽  
Karin Richter ◽  
Uwe Rauch ◽  
Reinhard Fässler ◽  
Craig C. Garner ◽  
...  

1994 ◽  
Vol 659 (1-2) ◽  
pp. 292-297 ◽  
Author(s):  
Anthony L. McCall ◽  
Antonia M. Van Bueren ◽  
Melissa Moholt-Siebert ◽  
Nicola J. Cherry ◽  
William R. Woodward

1993 ◽  
Vol 90 (20) ◽  
pp. 9635-9639 ◽  
Author(s):  
I. Tooyama ◽  
H. Abe ◽  
T. Renda ◽  
V. Erspamer ◽  
H. Kimura

Neuroscience ◽  
1996 ◽  
Vol 71 (1) ◽  
pp. 89-100 ◽  
Author(s):  
S. Chen ◽  
R. Bing ◽  
N. rosenblum ◽  
D.E. Hillman

2003 ◽  
Vol 459 (3) ◽  
pp. 251-266 ◽  
Author(s):  
Anthony P. Nicholas ◽  
Jeffrey L. King ◽  
Thiagarajan Sambandam ◽  
Joshua D. Echols ◽  
Kiran B. Gupta ◽  
...  

Neuroscience ◽  
2003 ◽  
Vol 121 (3) ◽  
pp. 573-586 ◽  
Author(s):  
C.Q Tilelli ◽  
A.R Martins ◽  
R.E Larson ◽  
N Garcia-Cairasco

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