Neuroprotective effect of N-acetyl-aspartyl-glutamate in combination with mild hypothermia in the endothelin-1 rat model of focal cerebral ischaemia

2005 ◽  
Vol 95 (5) ◽  
pp. 1287-1297 ◽  
Author(s):  
An Van Hemelrijck ◽  
Said Hachimi-Idrissi ◽  
Sophie Sarre ◽  
Guy Ebinger ◽  
Yvette Michotte
Keyword(s):  
Rat Model ◽  
Cerebral Ischaemia ◽  
Mild Hypothermia ◽  
Neuroprotective Effect ◽  
Focal Cerebral Ischaemia ◽  
Endothelin 1

The neuroprotective effect of a potent and selective inhibitor of type I NOS (L-MIN) in a rat model of focal cerebral ischaemia

Neuroreport ◽  
1995 ◽  
Vol 6 (11) ◽  
pp. 1541-1545 ◽  
Author(s):  
Toshiaki Nagafuji ◽  
Masakazu Sugiyama ◽  
Atsushi Muto ◽  
Toshihiko Makino ◽  
Tatsuo Miyauchi ◽  
...  
Keyword(s):  
Rat Model ◽  
Cerebral Ischaemia ◽  
Neuroprotective Effect ◽  
Selective Inhibitor ◽  
Type I ◽  
Focal Cerebral Ischaemia

Neuroprotective effect of aspirin by inhibition of glutamate release after permanent focal cerebral ischaemia in rats

2008 ◽  
Vol 79 (2) ◽  
pp. 456-459 ◽  
Author(s):  
Javier De Cristóbal ◽  
María A. Moro ◽  
Antoni Dávalos ◽  
José Castillo ◽  
Juan C. Leza ◽  
...  
Keyword(s):  
Cerebral Ischaemia ◽  
Neuroprotective Effect ◽  
Glutamate Release ◽  
Focal Cerebral Ischaemia

Neuroprotective Effect of the χ-Agonist Enadoline (CI-977) in Rat Models of Focal Cerebral Ischaemia

1993 ◽  
Vol 5 (7) ◽  
pp. 961-967 ◽  
Author(s):  
Neil James Hayward ◽  
Alexander Thorburn McKnight ◽  
Geoffrey Neil Woodruff
Keyword(s):  
Cerebral Ischaemia ◽  
Neuroprotective Effect ◽  
Focal Cerebral Ischaemia ◽  
Rat Models

scholarly journals Perivascular Microapplication of Endothelin-1: A New Model of Focal Cerebral Ischaemia in the Rat

1993 ◽  
Vol 13 (5) ◽  
pp. 865-871 ◽  
Author(s):  
John Sharkey
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Cerebral Ischaemia ◽  
Dorsal Hippocampus ◽  
Focal Cerebral Ischaemia ◽  
Local Cerebral Blood Flow ◽  
Guide Cannula ◽  
Conscious Rat ◽  
Endothelin 1 ◽  
Arterial Blood

In the present study, we describe the effects of perivascular microapplication of the potent vasoconstrictor peptide endothelin-1 (Et-1; (120 pmol in 3 μl), delivered via a guide cannula stereotaxically positioned above the left cerebral artery (MCA) of the conscious male Sprague–Dawley rat. Ten minutes after the administration of Et-1, mean arterial blood pressure had increased by 20% and profound reductions in local cerebral blood flow (up to 93%) were observed within those brain areas supplied by the MCA. In addition, significant increases in local cerebral blood flow were observed within the globus pallidus (100%), substantia nigra pars reticulata (48%), ventrolateral thalamus (65%), and dorsal hippocampus (74%) ipsilateral to the insult. Twenty-four hours following the insult, the pattern of ischaemic damage was similar to that reported previously following permanent occlusion of the rat MCA. It is suggested that perivascular microapplication of Et-1 may provide a useful model for the study of the functional disturbances associated with focal cerebral ischaemia in the conscious rat.

Topographic profile of reperfusion into MCA territory following endothelin-1-induced transient focal cerebral ischaemia

1996 ◽  
Vol 202 (3) ◽  
pp. 209-213 ◽  
Author(s):  
Gail Gartshore ◽  
Deborah Dawson ◽  
James Patterson ◽  
I.Mhairi Macrae
Keyword(s):  
Cerebral Ischaemia ◽  
Focal Cerebral Ischaemia ◽  
Endothelin 1 ◽  
Topographic Profile

scholarly journals Quantitative assessment of early brain damage in a rat model of focal cerebral ischaemia.

1987 ◽  
Vol 50 (4) ◽  
pp. 402-410 ◽  
Author(s):  
K A Osborne ◽  
T Shigeno ◽  
A M Balarsky ◽  
I Ford ◽  
J McCulloch ◽  
...  
Keyword(s):  
Brain Damage ◽  
Rat Model ◽  
Cerebral Ischaemia ◽  
Quantitative Assessment ◽  
Focal Cerebral Ischaemia

Neuroprotective Effect of Recombinant Neutrophil Inhibitory Factor in Transient Focal Cerebral Ischaemia in the Rat

1996 ◽  
Vol 5 (4) ◽  
pp. 319-323 ◽  
Author(s):  
Kenneth B. Mackay ◽  
Sarah J. Bailey ◽  
Penelope D. King ◽  
Sara Patel ◽  
Thomas C. Hamilton ◽  
...  
Keyword(s):  
Cerebral Ischaemia ◽  
Neuroprotective Effect ◽  
Inhibitory Factor ◽  
Focal Cerebral Ischaemia

Pre- and Post-treatment with Cyclosporine a in a Rat Model of Transient Focal Cerebral Ischaemia with Multimodal MRI Screening

2012 ◽  
Vol 8 (8) ◽  
pp. 669-674 ◽  
Author(s):  
Tae-Hee Cho ◽  
Pierre Aguettaz ◽  
Oscar Campuzano ◽  
Christiane Charriaut-Marlangue ◽  
Adrien Riou ◽  
...  
Keyword(s):  
Cyclosporine A ◽  
Rat Model ◽  
Cerebral Ischaemia ◽  
Post Treatment ◽  
Focal Cerebral Ischaemia ◽  
Multimodal Mri
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